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The Roles of Buyang Huanwu Decoction in Anti-Inflammation, Antioxidation and Regulation of Lipid Metabolism in Rats with Myocardial Ischemia
Joint Authors
Wang, Weirong
Fang, Zhiyuan
Zhang, Jiye
Shi, Xiaolian
Zhang, Hui
Lin, Rong
Ji, Qiaoli
Lin, Qinqin
Liu, Yu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Buyang Huanwu Decoction (BYHWD) is a well-known Chinese medicine formula.
Recent studies have reported that BYHWD can be used to treat ischemic heart disease.
This study investigated the potential mechanism underlying the roles of BYHWD in alleviating the myocardial ischemia induced by isoproterenol (ISO) in rats.
Different doses of BYHWD (25.68, 12.84 and 6.42 g kg−1) were lavaged to rats, respectively.
Then the expression of the cluster of differentiation 40 (CD40) in the mononuclear cells was measured using flow cytometry, and the expressions of CD40 and its ligand (CD40L) in myocardial tissues were determined by western blotting.
The serum biochemical values of superoxide dismutase (SOD) activity, the malondialdehyde (MDA) level and the free fatty acid (FFA) content were measured.
The results showed that the SOD activities of BYHWD groups were significantly higher than that of the ISO group, while the MDA levels and FFA contents of all BYHWD groups were lower than that of the ISO group.
BYHWD could decrease the expression of CD40 in the mononuclear cells and the CD40 and CD40L expressions in myocardial tissues.
Our data suggest that the roles of BYHWD are not only related to its antioxidative action and regulation of lipid metabolisms, but also to the inhibition of inflammatory pathway by the decreased CD40 and CD40L expressions in rats with myocardial ischemia.
American Psychological Association (APA)
Liu, Yu& Lin, Rong& Shi, Xiaolian& Fang, Zhiyuan& Wang, Weirong& Lin, Qinqin…[et al.]. 2011. The Roles of Buyang Huanwu Decoction in Anti-Inflammation, Antioxidation and Regulation of Lipid Metabolism in Rats with Myocardial Ischemia. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-480864
Modern Language Association (MLA)
Liu, Yu…[et al.]. The Roles of Buyang Huanwu Decoction in Anti-Inflammation, Antioxidation and Regulation of Lipid Metabolism in Rats with Myocardial Ischemia. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-480864
American Medical Association (AMA)
Liu, Yu& Lin, Rong& Shi, Xiaolian& Fang, Zhiyuan& Wang, Weirong& Lin, Qinqin…[et al.]. The Roles of Buyang Huanwu Decoction in Anti-Inflammation, Antioxidation and Regulation of Lipid Metabolism in Rats with Myocardial Ischemia. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-480864
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480864