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In Vitro Synergistic Effect of Curcumin in Combination with Third Generation Cephalosporins against Bacteria Associated with Infectious Diarrhea
Joint Authors
Jacob, Jubi
Nambisan, Bala
Sreekala, Sreerag Ravikumar
Sasidharan, Nishanth Kumar
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Diarrhea is one of the leading causes of morbidity and mortality in humans in developed and developing countries.
Furthermore, increased resistance to antibiotics has resulted in serious challenges in the treatment of this infectious disease worldwide.
Therefore, there exists a need to develop alternative natural or combination drug therapies.
The aim of the present study was to investigate the synergistic effect of curcumin-1 in combination with three antibiotics against five diarrhea causing bacteria.
The antibacterial activity of curcumin-1 and antibiotics was assessed by the broth microdilution method, checkerboard dilution test, and time-kill assay.
Antimicrobial activity of curcumin-1 was observed against all tested strains.
The MICs of curcumin-1 against test bacteria ranged from 125 to 1000 μg/mL.
In the checkerboard test, curcumin-1 markedly reduced the MICs of the antibiotics cefaclor, cefodizime, and cefotaxime.
Significant synergistic effect was recorded by curcumin-1 in combination with cefotaxime.
The toxicity of curcumin-1 with and without antibiotics was tested against foreskin (FS) normal fibroblast and no significant cytotoxicity was observed.
From our result it is evident that curcumin-1 enhances the antibiotic potentials against diarrhea causing bacteria in in vitro condition.
This study suggested that curcumin-1 in combination with antibiotics could lead to the development of new combination of antibiotics against diarrhea causing bacteria.
American Psychological Association (APA)
Sasidharan, Nishanth Kumar& Sreekala, Sreerag Ravikumar& Jacob, Jubi& Nambisan, Bala. 2014. In Vitro Synergistic Effect of Curcumin in Combination with Third Generation Cephalosporins against Bacteria Associated with Infectious Diarrhea. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-480869
Modern Language Association (MLA)
Sasidharan, Nishanth Kumar…[et al.]. In Vitro Synergistic Effect of Curcumin in Combination with Third Generation Cephalosporins against Bacteria Associated with Infectious Diarrhea. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-480869
American Medical Association (AMA)
Sasidharan, Nishanth Kumar& Sreekala, Sreerag Ravikumar& Jacob, Jubi& Nambisan, Bala. In Vitro Synergistic Effect of Curcumin in Combination with Third Generation Cephalosporins against Bacteria Associated with Infectious Diarrhea. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-480869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480869