Association of Plasma Circulatory Markers, Chlamydia pneumoniae, and High Sensitive C-Reactive Protein in Coronary Artery Disease Patients of India
Joint Authors
Prasad, Jagdish
Jha, Hem Chandra
Srivastava, Pragya
Mittal, Aruna Singh
Sarkar, Rakesh
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Plasma inflammatory markers have been shown to be predictors for cardiovascular risk, however, there is no study where the levels of plasma circulatory markers have been evaluated in coronary artery disease patients (CAD pts) positive for C.
pneumoniae IgA and high sensitive C-reactive protein (hsCRP) which may help in better understanding of disease pathogenesis.
A total of 192 patients and 192 controls attending the Cardiology Outpatient Department of Safdarjung Hospital were enrolled.
The levels of plasma circulatory inflammatory markers were evaluated by ELISA.
The levels of circulatory plasma markers (IL-4, IL-8, IL-13, ICAM-1, and VCAM-1) were significantly higher, whereas, levels of IL-10 and IFN-γ were significantly lower in CAD pts compared to healthy controls.
The levels of IL-4, IL-8, and ICAM-1 (P=.007, .015, and .048) were significantly higher, however, IL-10 and IFN-γ were significantly lower (P<.001, <.001) in C.
pneumoniae IgA positive CAD pts.
The levels of IL-4, IL-8, IL-13, ICAM-1, and VCAM-1 were higher but not significant and levels of IL-10 and IFN-γ were significantly (P<.001, <.001) lower in hsCRP positive CAD pts.
Our study suggested that circulatory cytokines, namely, IL-4, IL-8, and adhesive molecules like ICAM-1 were enhanced after infection with C.
pneumoniae whereas in contrast to this IL-10 and IFN-λ were lowered.
Suggesting the important role of these cytokines in progression of CAD.
American Psychological Association (APA)
Jha, Hem Chandra& Srivastava, Pragya& Sarkar, Rakesh& Prasad, Jagdish& Mittal, Aruna Singh. 2009. Association of Plasma Circulatory Markers, Chlamydia pneumoniae, and High Sensitive C-Reactive Protein in Coronary Artery Disease Patients of India. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-480875
Modern Language Association (MLA)
Jha, Hem Chandra…[et al.]. Association of Plasma Circulatory Markers, Chlamydia pneumoniae, and High Sensitive C-Reactive Protein in Coronary Artery Disease Patients of India. Mediators of Inflammation No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-480875
American Medical Association (AMA)
Jha, Hem Chandra& Srivastava, Pragya& Sarkar, Rakesh& Prasad, Jagdish& Mittal, Aruna Singh. Association of Plasma Circulatory Markers, Chlamydia pneumoniae, and High Sensitive C-Reactive Protein in Coronary Artery Disease Patients of India. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-480875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480875