Antidiabetic Properties of Azardiracta indica and Bougainvillea spectabilis : In Vivo Studies in Murine Diabetes Model
Joint Authors
Tirmale, Amruta R.
Bhat, Menakshi
Kothiwale, Sandeepkumar K.
Joshi, Bimba N.
Bhargava, Shobha Y.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Diabetes mellitus is a metabolic syndrome characterized by an increase in the blood glucose level.
Treatment of diabetes is complicated due to multifactorial nature of the disease.
Azadirachta indica Adr.
Juss and Bougainvillea spectabilis are reported to have medicinal values including antidiabetic properties.
In the present study using in vivo diabetic murine model, A.
indica and B.
spectabilis chloroform, methanolic and aqueous extracts were investigated for the biochemical parameters important for controlling diabetes.
It was found that A.
indica chloroform extract and B.
spectabilis aqueous, methanolic extracts showed a good oral glucose tolerance and significantly reduced the intestinal glucosidase activity.
Interestingly, A.
indica chloroform and B.
spectabilis aqueous extracts showed significant increase in glucose-6-phosphate dehydrogenase activity and hepatic, skeletal muscle glycogen content after 21 days of treatment.
In immunohistochemical analysis, we observed a regeneration of insulin-producing cells and corresponding increase in the plasma insulin and c-peptide levels with the treatment of A.
indica chloroform and B.
spectabilis aqueous, methanolic extracts.
Analyzing the results, it is clear that A.
indica chloroform and B.
spectabilis aqueous extracts are good candidates for developing new neutraceuticals treatment for diabetes.
American Psychological Association (APA)
Bhat, Menakshi& Kothiwale, Sandeepkumar K.& Tirmale, Amruta R.& Bhargava, Shobha Y.& Joshi, Bimba N.. 2011. Antidiabetic Properties of Azardiracta indica and Bougainvillea spectabilis : In Vivo Studies in Murine Diabetes Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-480882
Modern Language Association (MLA)
Bhat, Menakshi…[et al.]. Antidiabetic Properties of Azardiracta indica and Bougainvillea spectabilis : In Vivo Studies in Murine Diabetes Model. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-480882
American Medical Association (AMA)
Bhat, Menakshi& Kothiwale, Sandeepkumar K.& Tirmale, Amruta R.& Bhargava, Shobha Y.& Joshi, Bimba N.. Antidiabetic Properties of Azardiracta indica and Bougainvillea spectabilis : In Vivo Studies in Murine Diabetes Model. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-480882
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480882