GM-CSF Exhibits Anti-Inflammatory Activity on Endothelial Cells Derived from Chronic Venous Disease Patients
Joint Authors
Rimondi, Erika
Secchiero, Paola
Menegatti, Erica
Tisato, Veronica
Gianesini, Sergio
Zamboni, Paolo
Casciano, Fabio
Zauli, Giorgio
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Twenty patients affected by chronic venous disease (CVD) in tertiary venous network and/or saphenous vein were analyzed before surgical ablation by echo-color-doppler for the hemodynamic parameters reflux time (RT) and resistance index (RI), a negative and a positive prognostic factor, respectively.
RT and RI were next correlated with relevant in vitro parameters of venous endothelial cells (VEC) obtained from surgical specimens, such as cell migration in response to serum gradient, proliferation index, intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 expression, as well as cytokines release.
Of interest, ICAM-1 expression in patient-derived VEC cultures correlated positively with RT and negatively with RI.
Moreover, RT showed a positive correlation with the baseline osteoprotegerin (OPG) expression by VEC and an inverse correlation with VEC proliferation index.
On the other hand, RI correlated positively with TNF-related apoptosis inducing ligand (TRAIL) expression.
Among the cytokines released by VEC, GM-CSF showed a positive correlation with VEC proliferation and TRAIL expression and a negative correlation with OPG, ICAM-1 and VCAM-1 expression.
Since in vitro recombinant GM-CSF induced VEC proliferation and counteracted the induction of ICAM-1, VCAM-1 and OPG upon exposure to TNF-α, our data suggest an anti-inflammatory activity of GM-CSF on venous endothelial cells.
American Psychological Association (APA)
Tisato, Veronica& Secchiero, Paola& Rimondi, Erika& Gianesini, Sergio& Menegatti, Erica& Casciano, Fabio…[et al.]. 2013. GM-CSF Exhibits Anti-Inflammatory Activity on Endothelial Cells Derived from Chronic Venous Disease Patients. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-480888
Modern Language Association (MLA)
Tisato, Veronica…[et al.]. GM-CSF Exhibits Anti-Inflammatory Activity on Endothelial Cells Derived from Chronic Venous Disease Patients. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-480888
American Medical Association (AMA)
Tisato, Veronica& Secchiero, Paola& Rimondi, Erika& Gianesini, Sergio& Menegatti, Erica& Casciano, Fabio…[et al.]. GM-CSF Exhibits Anti-Inflammatory Activity on Endothelial Cells Derived from Chronic Venous Disease Patients. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-480888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480888