Autoimmune Hepatitis Triggered by Anti-TNF-α Therapy

Abstract EN

Autoimmune hepatitis (AIH) is occasionally triggered by drug treatments.

Recently, as biological agents are becoming widely used for autoimmune disorders, there have been a growing number of reports of the development of autoimmune processes related to these agents.

A 52-year-old Japanese woman with psoriasis developed liver damage two months after initiation of anti-TNF-α therapy with adalimumab.

Liver histological findings were compatible with AIH, and positive conversions of ANAs were detected.

The patient was treated with prednisolone and had a good response.

While some cases of AIH triggered by anti-TNF-α therapies have been reported, the pathogenesis remains unspecified.

When elevation of liver enzymes is observed with high IgG levels and seropositivity of ANA during the course of anti-TNF-α therapy, liver biopsy findings may be essential and important to make definitive diagnosis of AIH.