Molecular Mechanisms of Cigarette Smoke-Induced Proliferation of Lung Cells and Prevention by Vitamin C
Joint Authors
Chatterjee, Indu B.
Dey, Neekkan
Chattopadhyay, Dhruba J.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-31
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Lung cancer is the leading cause of cancer dearth.
Cigarette smoking is the strongest risk factor for developing lung cancer, which is conceivably initiated by proliferation.
Here, we show that low concentration of aqueous extract of cigarette smoke (AECS) causes excessive proliferation of human lung epithelial cells (A549) without any apoptotic cell death.
The causative factor responsible for AECS-induced proliferation has been identified as p-benzoquinone (p-BQ).
Coimmunoprecipitation and immunoblot experiments indicate that p-BQ binds with epidermal growth factor receptor (EGFR).
However, in contrast to EGF, it causes aberrant phosphorylation of EGFR that lacks c-Cbl-mediated ubiquitination and degradation resulting in persistent activation of EGFR.
This is followed by activation of Hras + Kras and the downstream survival and proliferative signaling molecules Akt and ERK1/2, as well as the nuclear transcription factors c-Myc and c-Fos.
Vitamin C and/or antibody to p-BQ prevents AECS/p-BQ-induced proliferation of lung cells apparently by inactivating p-BQ and thereby preventing activation of EGFR and the downstream signaling molecules.
The results suggest that vitamin C and/or antibody to p-BQ may provide a novel intervention for preventing initiation of lung cancer in smokers.
American Psychological Association (APA)
Dey, Neekkan& Chattopadhyay, Dhruba J.& Chatterjee, Indu B.. 2011. Molecular Mechanisms of Cigarette Smoke-Induced Proliferation of Lung Cells and Prevention by Vitamin C. Journal of Oncology،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-480905
Modern Language Association (MLA)
Dey, Neekkan…[et al.]. Molecular Mechanisms of Cigarette Smoke-Induced Proliferation of Lung Cells and Prevention by Vitamin C. Journal of Oncology No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-480905
American Medical Association (AMA)
Dey, Neekkan& Chattopadhyay, Dhruba J.& Chatterjee, Indu B.. Molecular Mechanisms of Cigarette Smoke-Induced Proliferation of Lung Cells and Prevention by Vitamin C. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-480905
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480905