The Inhibitory Effects of Aqueous Extract from Guava Twigs, Psidium guajava L., on Mutation and Oxidative Damage
Joint Authors
Wang, Bor-Sen
Tai, Shan-Pao
Kang, Zhi-Chyang
Chiu, Chih-Kwang
Huang, Shu-Ling
Yen, Ming-Tsung
Wu, Horng-Cherng
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
This study examines the inhibitory effects of the aqueous extract from guava twigs (GTE), Psidium guajava L., on mutation and oxidative damage.
The results show that GTE inhibits the mutagenicity of 4-nitroquinoline-N-oxide (4-NQO), a direct mutagen, and 2-aminoanthracene (2-AA), an indirect mutagen, toward Salmonella typhimurium TA 98 and TA 100.
In addition, GTE shows radical scavenging, reducing activities, tyrosinase inhibition, and liposome protection effects.
Meanwhile, GTE in the range of 0.1–0.4 mg/mL protects liver cells from tert-butyl-hydroperoxide-(t-BHP-) induced cytotoxicity.
Furthermore, the cytotoxicity inhibition of GTE in the t-BHP-treated cells was demonstrated in a dose-dependent manner.
High-performance liquid chromatography analysis suggests that the major phenolic constituents in GTE are gallic acid, ferulic acid, and myricetin.
These active phenolic components may contribute to the biological protective effects of GTE in different models.
The data suggest that GTE exhibiting biological activities can be applied to antimutation, antityrosinase, and antioxidative damage.
American Psychological Association (APA)
Kang, Zhi-Chyang& Yen, Ming-Tsung& Chiu, Chih-Kwang& Wu, Horng-Cherng& Huang, Shu-Ling& Tai, Shan-Pao…[et al.]. 2012. The Inhibitory Effects of Aqueous Extract from Guava Twigs, Psidium guajava L., on Mutation and Oxidative Damage. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-480910
Modern Language Association (MLA)
Kang, Zhi-Chyang…[et al.]. The Inhibitory Effects of Aqueous Extract from Guava Twigs, Psidium guajava L., on Mutation and Oxidative Damage. Journal of Chemistry No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-480910
American Medical Association (AMA)
Kang, Zhi-Chyang& Yen, Ming-Tsung& Chiu, Chih-Kwang& Wu, Horng-Cherng& Huang, Shu-Ling& Tai, Shan-Pao…[et al.]. The Inhibitory Effects of Aqueous Extract from Guava Twigs, Psidium guajava L., on Mutation and Oxidative Damage. Journal of Chemistry. 2012. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-480910
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480910