Human Polyomavirus-Associated Cerebral Disorders in the Post-HAART Era
Joint Authors
Cedeno-Laurent, Filiberto
Penalva de Oliveira, Augusto C.
Vidal, José E.
Trujillo, J. Roberto
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-22
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Human polyomavirus JC is the causative agent of a deadly form of sudden onset dementia, progressive multifocal leukocoencephalopathy (PML).
PML is highly prevalent in immunodeficient populations, specially those undergoing chemotherapy, immunosuppressive treatments for autoimmune conditions, and HIV-1/AIDS patients.
In fact, before the highly active antiretroviral therapy (HAART) regimens became available, PML was a leading cause of death in HIV-1 seropositive individuals.
However, patients under HAART show increased survival times with better prognoses.
In this report we described the main differences between PML before and after the HAART era; highlighting the new patterns of presentation, the neurotropism of other human polyomaviruses, and the increased prevalence of immune reconstitution inflammatory syndrome (IRIS), as a complication of PML in patients under HAART.
Lastly, we propose a revised classification of human poliomavirus-associated cerebral disorders that may reflect more accurately what clinicians encounter in their everyday practice.
American Psychological Association (APA)
Cedeno-Laurent, Filiberto& Penalva de Oliveira, Augusto C.& Vidal, José E.& Trujillo, J. Roberto. 2011. Human Polyomavirus-Associated Cerebral Disorders in the Post-HAART Era. Pathology Research International،Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-480953
Modern Language Association (MLA)
Cedeno-Laurent, Filiberto…[et al.]. Human Polyomavirus-Associated Cerebral Disorders in the Post-HAART Era. Pathology Research International No. 2011 (2011), pp.1-3.
https://search.emarefa.net/detail/BIM-480953
American Medical Association (AMA)
Cedeno-Laurent, Filiberto& Penalva de Oliveira, Augusto C.& Vidal, José E.& Trujillo, J. Roberto. Human Polyomavirus-Associated Cerebral Disorders in the Post-HAART Era. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-480953
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480953