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PAI-1 : An Integrator of Cell Signaling and Migration
Joint Authors
Freytag, Jennifer
Samarakoon, Rohan
Higgins, Craig E.
Wilkins-Port, Cynthia E.
Higgins, Stephen P.
Higgins, Paul J.
Czekay, Ralf-Peter
Klein, R. Matthew
Overstreet, Jessica M.
Source
International Journal of Cell Biology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cellular migration, over simple surfaces or through complex stromal barriers, requires coordination between detachment/re-adhesion cycles, involving structural components of the extracellular matrix and their surface-binding elements (integrins), and the precise regulation of the pericellular proteolytic microenvironment.
It is now apparent that several proteases and protease inhibitors, most notably urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type-1 (PAI-1), also interact with several cell surface receptors transducing intracellular signals that significantly affect both motile and proliferative programs.
These events appear distinct from the original function of uPA/PAI-1 as modulators of the plasmin-based proteolytic cascade.
The multifaceted interactions of PAI-1 with specific matrix components (i.e., vitronectin), the low-density lipoprotein receptor-related protein-1 (LRP1), and the uPA/uPA receptor complex have dramatic consequences on the migratory phenotype and may underlie the pathophysiologic sequalae of PAI-1 deficiency and overexpression.
This paper focuses on the increasingly intricate role of PAI-1 as a major mechanistic determinant of the cellular migratory phenotype.
American Psychological Association (APA)
Czekay, Ralf-Peter& Wilkins-Port, Cynthia E.& Higgins, Stephen P.& Freytag, Jennifer& Overstreet, Jessica M.& Klein, R. Matthew…[et al.]. 2011. PAI-1 : An Integrator of Cell Signaling and Migration. International Journal of Cell Biology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-480957
Modern Language Association (MLA)
Czekay, Ralf-Peter…[et al.]. PAI-1 : An Integrator of Cell Signaling and Migration. International Journal of Cell Biology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-480957
American Medical Association (AMA)
Czekay, Ralf-Peter& Wilkins-Port, Cynthia E.& Higgins, Stephen P.& Freytag, Jennifer& Overstreet, Jessica M.& Klein, R. Matthew…[et al.]. PAI-1 : An Integrator of Cell Signaling and Migration. International Journal of Cell Biology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-480957
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480957