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Fatal H1N1-Related Acute Necrotizing Encephalopathy in an Adult
Joint Authors
Siegel, Robert D.
Rao, Vivek A.
Lee, Yu-Jin
Flint, Alexander C.
Kosek, Jon
Smith, D. Scott
Glaser, Carol A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-28
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Acute necrotizing encephalopathy (ANE) is a severe neurological complication of influenza infection, including H1N1 influenza.
Many cases of ANE have been reported in the pediatric literature, but very few cases have been described in adults.
The cause of ANE remains unknown—the influenza virus is not known to be neurotropic, and evidence of direct viral involvement of the central nervous system (CNS) has not been demonstrated in the limited cases of ANE in which pathological specimens have been obtained.
Here we report a fatal case of ANE from H1N1 influenza infection in an adult.
Neuroimaging and postmortem analysis both showed widespread brain edema, necrosis, and hemorrhage, but molecular studies and postmortem pathology revealed no evidence of direct viral involvement of the CNS.
This case of fatal ANE in an adult is consistent with the hypothesis generated from pediatric cases that the host immune response, and not direct viral invasion of the CNS, is responsible for pathogenesis of ANE.
American Psychological Association (APA)
Lee, Yu-Jin& Smith, D. Scott& Rao, Vivek A.& Siegel, Robert D.& Kosek, Jon& Glaser, Carol A.…[et al.]. 2011. Fatal H1N1-Related Acute Necrotizing Encephalopathy in an Adult. Case Reports in Critical Care،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-480962
Modern Language Association (MLA)
Lee, Yu-Jin…[et al.]. Fatal H1N1-Related Acute Necrotizing Encephalopathy in an Adult. Case Reports in Critical Care No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-480962
American Medical Association (AMA)
Lee, Yu-Jin& Smith, D. Scott& Rao, Vivek A.& Siegel, Robert D.& Kosek, Jon& Glaser, Carol A.…[et al.]. Fatal H1N1-Related Acute Necrotizing Encephalopathy in an Adult. Case Reports in Critical Care. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-480962
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480962