Long-Term Effects of Antiviral Therapy in Patients with Chronic Hepatitis C
Joint Authors
Keeffe, Emmet B.
Kagawa, Tatehiro
Source
Hepatitis Research and Treatment
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Chronic hepatitis C is a major cause of chronic liver disease globally, and the natural history of progression may lead to cirrhosis with liver failure, hepatocellular carcinoma, and premature liver-related death.
Emerging data demonstrates that interferon-based therapy, particularly among those achieving a sustained virologic response (SVR), is associated with long-term persistence of SVR, improved fibrosis and inflammation scores, reduced incidence of hepatocellular carcinoma, and prolonged life expectancy.
This reduction in the rate of progression has also been demonstrated in patients with chronic hepatitis C and cirrhosis in some but not all studies.
The majority of these results are reported with standard interferon therapy, and long-term results of peginterferon plus ribavirin therapy with a higher likelihood of SVR should have a yet greater impact on the population of treated patients.
The impact on slowing progression is greatest in patients with an SVR, less in relapsers, and equivocal in nonresponders.
Thus, the natural history of chronic hepatitis C after completion of antiviral therapy is favorable with achievement of an SVR, although further data are needed to determine the likely incremental impact of peginterferon plus ribavirin, late long-term effects of therapy, and the benefit of treatment in patients with advanced hepatic fibrosis.
American Psychological Association (APA)
Kagawa, Tatehiro& Keeffe, Emmet B.. 2010. Long-Term Effects of Antiviral Therapy in Patients with Chronic Hepatitis C. Hepatitis Research and Treatment،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-480968
Modern Language Association (MLA)
Kagawa, Tatehiro& Keeffe, Emmet B.. Long-Term Effects of Antiviral Therapy in Patients with Chronic Hepatitis C. Hepatitis Research and Treatment No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-480968
American Medical Association (AMA)
Kagawa, Tatehiro& Keeffe, Emmet B.. Long-Term Effects of Antiviral Therapy in Patients with Chronic Hepatitis C. Hepatitis Research and Treatment. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-480968
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480968