Acute Rhabdomyolysis Associated with Coadministration of Levofloxacin and Simvastatin in a Patient with Normal Renal Function
Joint Authors
Paparoupa, Maria
Pietrzak, Sebastian
Gillissen, Adrian
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-22
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
We report a rare case of severe acute rhabdomyolysis in association with coadministration of levofloxacin and simvastatin in a patient with normal renal function.
A 70-year-old Caucasian male was treated due to community acquired pneumonia with levofloxacin in a dosage of 500 mg once and then twice a day.
On the 8th day of hospitalization the patient presented with acute severe rhabdomyolysis requiring an intensive care support.
After discontinuation of levofloxacin and concomitant medication with simvastatin 80 mg/day, clinical and laboratory effects were totally reversible.
Up to now, levofloxacin has been reported to induce rhabdomyolysis mainly in patients with impaired renal function, as the medication has a predominant renal elimination.
In our case renal function remained normal during the severe clinical course.
According to a recent case report rhabdomyolysis was observed due to interaction of simvastatin and ciprofloxacin.
To our best knowledge this is the first case of interaction between simvastatin and levofloxacin to be reported.
This case emphasizes the need of close monitoring of creatine kinase in patients under more than one potentially myotoxic medication especially when patients develop muscle weakness.
American Psychological Association (APA)
Paparoupa, Maria& Pietrzak, Sebastian& Gillissen, Adrian. 2014. Acute Rhabdomyolysis Associated with Coadministration of Levofloxacin and Simvastatin in a Patient with Normal Renal Function. Case Reports in Medicine،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-481001
Modern Language Association (MLA)
Paparoupa, Maria…[et al.]. Acute Rhabdomyolysis Associated with Coadministration of Levofloxacin and Simvastatin in a Patient with Normal Renal Function. Case Reports in Medicine No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-481001
American Medical Association (AMA)
Paparoupa, Maria& Pietrzak, Sebastian& Gillissen, Adrian. Acute Rhabdomyolysis Associated with Coadministration of Levofloxacin and Simvastatin in a Patient with Normal Renal Function. Case Reports in Medicine. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-481001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481001