The Caspase Pathway as a Possible Therapeutic Target in Experimental Pemphigus
Joint Authors
López-Luna, Argelia
Herrera-Esparza, Rafael
Avalos-Díaz, Esperanza
Pacheco-Tovar, Deyanira
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Apoptosis plays a role in pemphigus IgG-dependent acantholysis; theoretically, the blockade of the caspase pathway could prevent the blistering that is caused by pemphigus autoantibodies.
Using this strategy, we attempted to block the pathogenic effect of pemphigus IgG in Balb/c mice by using the caspase inhibitor Ac-DEVD-CMK.
This inhibitor was administrated before the injection of pemphigus IgG into neonatal mice.
The main results of the present investigation are as follows: (1) pemphigus IgG induces intraepidermal blisters in Balb/c neonatal mice; (2) keratinocytes around the blister and acantholytic cells undergo apoptosis; (3) the caspases inhibitor Ac-DEVD-CMK prevents apoptosis; (4) the inhibition of the caspase pathway prevents blister formation.
In conclusion, inhibition of the caspase pathway may be a promising therapeutic tool that can help in the treatment of pemphigus flare ups.
American Psychological Association (APA)
Pacheco-Tovar, Deyanira& López-Luna, Argelia& Herrera-Esparza, Rafael& Avalos-Díaz, Esperanza. 2011. The Caspase Pathway as a Possible Therapeutic Target in Experimental Pemphigus. Autoimmune Diseases،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-481018
Modern Language Association (MLA)
Pacheco-Tovar, Deyanira…[et al.]. The Caspase Pathway as a Possible Therapeutic Target in Experimental Pemphigus. Autoimmune Diseases No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-481018
American Medical Association (AMA)
Pacheco-Tovar, Deyanira& López-Luna, Argelia& Herrera-Esparza, Rafael& Avalos-Díaz, Esperanza. The Caspase Pathway as a Possible Therapeutic Target in Experimental Pemphigus. Autoimmune Diseases. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-481018
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481018