Histological, Histochemical, and Protein Changes after Induced Malocclusion by Occlusion Alteration of Wistar Rats
Joint Authors
Iyomasa, Mamie Mizusaki
Galisteu Luiz, Kelly
Del Bel Guimarães, Elaine A.
Carla Lara Pereira, Yamba
Gerlach, Raquel Fernanda
de Souza Guerra, Carolina
Issa, João Paulo Mardegan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Although disorders of the stomatognathic system are common, the mechanisms involved are unknown.
Our objective was to study the changes in the masseter muscles after unilateral exodontia.
Molar extraction was performed on Wistar rats (left side), and the animals were sacrificed after either 14 or 26 days.
The masseter muscle was processed for histological analysis, conventional and in situ zymography, and immunohistochemistry.
The morphological analysis showed unique and specific characteristics for the experimental group.
By conventional zymography no significant values of 72 kDa MMP-2 (P< 0.05) were found in both of the sides of masseter muscle after 14 and 26 days of unilateral extraction.
The in situ zymography showed gelatinolytic activity on all deep masseter muscles, with significant increase on the contralateral side after 14 and 26 days (P< 0.05).
The immunohistochemistry demonstrated greater expression of MMP-2 than MMP-9 and MMP-14 in all masseter muscles and there were few differences in the staining of 4 TIMPs.
This knowledge about morphology and molecular masticatory muscle remodeling following environmental interventions can be used to develop clinically successful treatments.
American Psychological Association (APA)
de Souza Guerra, Carolina& Carla Lara Pereira, Yamba& Issa, João Paulo Mardegan& Galisteu Luiz, Kelly& Del Bel Guimarães, Elaine A.& Gerlach, Raquel Fernanda…[et al.]. 2014. Histological, Histochemical, and Protein Changes after Induced Malocclusion by Occlusion Alteration of Wistar Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-481054
Modern Language Association (MLA)
de Souza Guerra, Carolina…[et al.]. Histological, Histochemical, and Protein Changes after Induced Malocclusion by Occlusion Alteration of Wistar Rats. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-481054
American Medical Association (AMA)
de Souza Guerra, Carolina& Carla Lara Pereira, Yamba& Issa, João Paulo Mardegan& Galisteu Luiz, Kelly& Del Bel Guimarães, Elaine A.& Gerlach, Raquel Fernanda…[et al.]. Histological, Histochemical, and Protein Changes after Induced Malocclusion by Occlusion Alteration of Wistar Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-481054
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481054