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On the G-Protein-Coupled Receptor Heteromers and Their Allosteric Receptor-Receptor Interactions in the Central Nervous System : Focus on Their Role in Pain Modulation
Joint Authors
Romero-Fernandez, Wilber
Rivera, Alicia
Agnati, Luigi F.
Tarakanov, Alexander O.
Borroto-Escuela, Dasiel O.
Van Craenenbroeck, Kathleen
Fuxe, Kjell
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-17
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The modulatory role of allosteric receptor-receptor interactions in the pain pathways of the Central Nervous System and the peripheral nociceptors has become of increasing interest.
As integrators of nociceptive and antinociceptive wiring and volume transmission signals, with a major role for the opioid receptor heteromers, they likely have an important role in the pain circuits and may be involved in acupuncture.
The delta opioid receptor (DOR) exerts an antagonistic allosteric influence on the mu opioid receptor (MOR) function in a MOR-DOR heteromer.
This heteromer contributes to morphine-induced tolerance and dependence, since it becomes abundant and develops a reduced G-protein-coupling with reduced signaling mainly operating via β-arrestin2 upon chronic morphine treatment.
A DOR antagonist causes a return of the Gi/o binding and coupling to the heteromer and the biological actions of morphine.
The gender- and ovarian steroid-dependent recruitment of spinal cord MOR/kappa opioid receptor (KOR) heterodimers enhances antinociceptive functions and if impaired could contribute to chronic pain states in women.
MOR1D heterodimerizes with gastrin-releasing peptide receptor (GRPR) in the spinal cord, mediating morphine induced itch.
Other mechanism for the antinociceptive actions of acupuncture along meridians may be that it enhances the cross-desensitization of the TRPA1 (chemical nociceptor)-TRPV1 (capsaicin receptor) heteromeric channel complexes within the nociceptor terminals located along these meridians.
Selective ionotropic cannabinoids may also produce cross-desensitization of the TRPA1-TRPV1 heteromeric nociceptor channels by being negative allosteric modulators of these channels leading to antinociception and antihyperalgesia.
American Psychological Association (APA)
Borroto-Escuela, Dasiel O.& Romero-Fernandez, Wilber& Rivera, Alicia& Van Craenenbroeck, Kathleen& Tarakanov, Alexander O.& Agnati, Luigi F.…[et al.]. 2013. On the G-Protein-Coupled Receptor Heteromers and Their Allosteric Receptor-Receptor Interactions in the Central Nervous System : Focus on Their Role in Pain Modulation. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-481069
Modern Language Association (MLA)
Borroto-Escuela, Dasiel O.…[et al.]. On the G-Protein-Coupled Receptor Heteromers and Their Allosteric Receptor-Receptor Interactions in the Central Nervous System : Focus on Their Role in Pain Modulation. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-481069
American Medical Association (AMA)
Borroto-Escuela, Dasiel O.& Romero-Fernandez, Wilber& Rivera, Alicia& Van Craenenbroeck, Kathleen& Tarakanov, Alexander O.& Agnati, Luigi F.…[et al.]. On the G-Protein-Coupled Receptor Heteromers and Their Allosteric Receptor-Receptor Interactions in the Central Nervous System : Focus on Their Role in Pain Modulation. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-481069
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481069