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Synthesis, Solution, and Structural Characterization of Tetrahydrofuranyl-2,2-Bisphosphonic Acid Disodium Salt
Joint Authors
Maltezou, Elena
Roy, Sudeshna
Drouza, Chryssoula
Keramidas, Anastasios D.
Stylianou, Marios
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Bisphosphonates are biologically relevant therapeutics for bone disorders and cancer.
Reaction of γ-chlorobutyric acid, phosphorus acid, and phosphorus trichloride without the use of solvent gave the tetrahydrofuranyl-2,2-bisphosphonate sodium salt (Na2H2L).
The Na2H2L was isolated, characterized in solution by 1H, 13C, and 31P NMR spectroscopy and in solid state by single X-Ray crystallography.
The crystal structure showed that the Na2H2L forms in the crystal infinite two-dimensional sheets stacked one parallel to the other.
A comparison of the chelating properties of H2L2− with similar hydroxyl bisphosphonate ligands shows that the strength of the Na–O(furanyl/hydroxyl) bond is directly related to the total charge of the ligand anion.
American Psychological Association (APA)
Maltezou, Elena& Stylianou, Marios& Roy, Sudeshna& Drouza, Chryssoula& Keramidas, Anastasios D.. 2010. Synthesis, Solution, and Structural Characterization of Tetrahydrofuranyl-2,2-Bisphosphonic Acid Disodium Salt. Bioinorganic Chemistry and Applications،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-481084
Modern Language Association (MLA)
Maltezou, Elena…[et al.]. Synthesis, Solution, and Structural Characterization of Tetrahydrofuranyl-2,2-Bisphosphonic Acid Disodium Salt. Bioinorganic Chemistry and Applications No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-481084
American Medical Association (AMA)
Maltezou, Elena& Stylianou, Marios& Roy, Sudeshna& Drouza, Chryssoula& Keramidas, Anastasios D.. Synthesis, Solution, and Structural Characterization of Tetrahydrofuranyl-2,2-Bisphosphonic Acid Disodium Salt. Bioinorganic Chemistry and Applications. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-481084
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481084