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Mesenchymal Stem Cell Therapy Modulates the Inflammatory Response in Experimental Traumatic Brain Injury
Joint Authors
Camara, Niels Olsen Saraiva
Semedo, Patricia
Ariza, Carolina Batista
Galindo, Layla T.
Filippo, Thais R. M.
Moreira, Caroline M.
Porcionatto, Marimelia A.
Source
Neurology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Therapy with mesenchymal stem cells (MSCs) has showed to be promising due to its immunomodulatory function.
Traumatic brain injury (TBI) triggers immune response and release of inflammatory mediators, mainly cytokines, by glial cells creating a hostile microenvironment for endogenous neural stem cells (NSCs).
We investigated the effects of factors secreted by MSCs on NSC in vitro and analyzed cytokines expression in vitro in a TBI model.
Our in vitro results show that MSC-secreted factors increase NSC proliferation and induce higher expression of GFAP, indicating a tendency toward differentiation into astrocytes.
In vivo experiments showed that MSC injection at an acute model of brain injury diminishes a broad profile of cytokines in the tissue, suggesting that MSC-secreted factors may modulate the inflammation at the injury site, which may be of interest to the development of a favorable microenvironment for endogenous NSC and consequently to repair the injured tissue.
American Psychological Association (APA)
Galindo, Layla T.& Filippo, Thais R. M.& Semedo, Patricia& Ariza, Carolina Batista& Moreira, Caroline M.& Camara, Niels Olsen Saraiva…[et al.]. 2011. Mesenchymal Stem Cell Therapy Modulates the Inflammatory Response in Experimental Traumatic Brain Injury. Neurology Research International،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-481101
Modern Language Association (MLA)
Galindo, Layla T.…[et al.]. Mesenchymal Stem Cell Therapy Modulates the Inflammatory Response in Experimental Traumatic Brain Injury. Neurology Research International No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-481101
American Medical Association (AMA)
Galindo, Layla T.& Filippo, Thais R. M.& Semedo, Patricia& Ariza, Carolina Batista& Moreira, Caroline M.& Camara, Niels Olsen Saraiva…[et al.]. Mesenchymal Stem Cell Therapy Modulates the Inflammatory Response in Experimental Traumatic Brain Injury. Neurology Research International. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-481101
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481101