Synergistic Effects of Toxic Elements on Heat Shock Proteins
Joint Authors
Jadoon, Saima
Hussain, Jamshaid
Mahmood, Khalid
Mahmood, Qaisar
Irshad, Muhammad
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-20
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Heat shock proteins show remarkable variations in their expression levels under a variety of toxic conditions.
A research span expanded over five decades has revealed their molecular characterization, gene regulation, expression patterns, vast similarity in diverse groups, and broad range of functional capabilities.
Their functions include protection and tolerance against cytotoxic conditions through their molecular chaperoning activity, maintaining cytoskeleton stability, and assisting in cell signaling.
However, their role as biomarkers for monitoring the environmental risk assessment is controversial due to a number of conflicting, validating, and nonvalidating reports.
The current knowledge regarding the interpretation of HSPs expression levels has been discussed in the present review.
The candidature of heat shock proteins as biomarkers of toxicity is thus far unreliable due to synergistic effects of toxicants and other environmental factors.
The adoption of heat shock proteins as “suit of biomarkers in a set of organisms” requires further investigation.
American Psychological Association (APA)
Mahmood, Khalid& Jadoon, Saima& Mahmood, Qaisar& Irshad, Muhammad& Hussain, Jamshaid. 2014. Synergistic Effects of Toxic Elements on Heat Shock Proteins. BioMed Research International،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-481110
Modern Language Association (MLA)
Mahmood, Khalid…[et al.]. Synergistic Effects of Toxic Elements on Heat Shock Proteins. BioMed Research International No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-481110
American Medical Association (AMA)
Mahmood, Khalid& Jadoon, Saima& Mahmood, Qaisar& Irshad, Muhammad& Hussain, Jamshaid. Synergistic Effects of Toxic Elements on Heat Shock Proteins. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-481110
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481110