Interleukin-16 Polymorphism Is Associated with an Increased Risk of Ischemic Stroke
Joint Authors
Li, Ya-guo
Liu, Xiao-li
Zhou, Yu-miao
Shu, Qin-fen
Du, Jian-zong
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Clinical and experimental data have demonstrated that inflammation plays fundamental roles in the pathogenesis of ischemic stroke.
Interleukin-16 (IL-16) is identified as a proinflammatory cytokine that is a key element in the ischemic cascade after cerebral ischemia.
We aimed to examine the relationship between the IL-16 polymorphisms and the risk of ischemic stroke in a Chinese population.
A total of 198 patients with ischemic stroke and 236 controls were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing method.
We found that the rs11556218TG genotype and G allele of IL-16 were associated with significantly increased risks of ischemic stroke (TG versus TT, adjusted OR = 1.88; 95% CI, 1.15–3.07; G versus T, adjusted OR = 1.54; 95% CI, 1.05–2.27, resp.).
However, there were no significant differences in the genotype and allele frequencies of IL-16 rs4778889 T/C and rs4072111 C/T polymorphisms between the two groups, even after stratification analyses by age, gender, and the presence or absence of hypertension, diabetes mellitus, hypercholesterolemia, and hypertriglyceridemia.
These findings indicate that the IL-16 polymorphism may be related to the etiology of ischemic stroke in the Chinese population.
American Psychological Association (APA)
Liu, Xiao-li& Du, Jian-zong& Zhou, Yu-miao& Shu, Qin-fen& Li, Ya-guo. 2013. Interleukin-16 Polymorphism Is Associated with an Increased Risk of Ischemic Stroke. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-481162
Modern Language Association (MLA)
Liu, Xiao-li…[et al.]. Interleukin-16 Polymorphism Is Associated with an Increased Risk of Ischemic Stroke. Mediators of Inflammation No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-481162
American Medical Association (AMA)
Liu, Xiao-li& Du, Jian-zong& Zhou, Yu-miao& Shu, Qin-fen& Li, Ya-guo. Interleukin-16 Polymorphism Is Associated with an Increased Risk of Ischemic Stroke. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-481162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481162