Meta-Analysis of Low Density Lipoprotein Receptor (LDLR) rs2228671 Polymorphism and Coronary Heart Disease
Joint Authors
Zhao, Qianlei
Wang, Chunming
Dai, Dongjun
Wang, Lingyan
Huang, Yi
Ye, Huadan
Duan, Shiwei
Xu, Leiting
Liu, Haibo
Ye, Meng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Low density lipoprotein receptor (LDLR) can regulate cholesterol metabolism by removing the excess low density lipoprotein cholesterol (LDL-C) in blood.
Since cholesterol metabolism is often disrupted in coronary heart disease (CHD), LDLR as a candidate gene of CHD has been intensively studied.
The goal of our study is to evaluate the overall contribution of LDLR rs2228671 polymorphism to the risk of CHD by combining the genotyping data from multiple case-control studies.
Our meta-analysis is involved with 8 case-control studies among 7588 cases and 9711 controls to test the association between LDLR rs2228671 polymorphism and CHD.
In addition, we performed a case-control study of LDLR rs2228671 polymorphism with the risk of CHD in Chinese population.
Our meta-analysis showed that rs2228671-T allele was significantly associated with a reduced risk of CHD (P=0.0005, odds ratio (OR) = 0.83, and 95% confidence interval (95% CI) = 0.75–0.92).
However, rs2228671-T allele frequency was rare (1%) and was not associated with CHD in Han Chinese (P=0.49), suggesting an ethnic difference of LDLR rs2228671 polymorphism.
Meta-analysis has established rs2228671 as a protective factor of CHD in Europeans.
The lack of association in Chinese reflects an ethnic difference of this genetic variant between Chinese and European populations.
American Psychological Association (APA)
Ye, Huadan& Zhao, Qianlei& Huang, Yi& Wang, Lingyan& Liu, Haibo& Wang, Chunming…[et al.]. 2014. Meta-Analysis of Low Density Lipoprotein Receptor (LDLR) rs2228671 Polymorphism and Coronary Heart Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-481186
Modern Language Association (MLA)
Ye, Huadan…[et al.]. Meta-Analysis of Low Density Lipoprotein Receptor (LDLR) rs2228671 Polymorphism and Coronary Heart Disease. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-481186
American Medical Association (AMA)
Ye, Huadan& Zhao, Qianlei& Huang, Yi& Wang, Lingyan& Liu, Haibo& Wang, Chunming…[et al.]. Meta-Analysis of Low Density Lipoprotein Receptor (LDLR) rs2228671 Polymorphism and Coronary Heart Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-481186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481186