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A Toolbox for Predicting G-Quadruplex Formation and Stability
Joint Authors
Huppert, Julian Leon
Rodgers, Simon
Stegle, Oliver
Wong, Han Min
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
G-quadruplexes are four stranded nucleic acid structures formed around a core of guanines, arranged in squares with mutual hydrogen bonding.
Many of these structures are highly thermally stable, especially in the presence of monovalent cations, such as those found under physiological conditions.
Understanding of their physiological roles is expanding rapidly, and they have been implicated in regulating gene transcription and translation among other functions.
We have built a community-focused website to act as a repository for the information that is now being developed.
At its core, this site has a detailed database (QuadDB) of predicted G-quadruplexes in the human and other genomes, together with the predictive algorithm used to identify them.
We also provide a QuadPredict server, which predicts thermal stability and acts as a repository for experimental data from all researchers.
There are also a number of other data sources with computational predictions.
We anticipate that the wide availability of this information will be of use both to researchers already active in this exciting field and to those who wish to investigate a particular gene hypothesis.
American Psychological Association (APA)
Wong, Han Min& Stegle, Oliver& Rodgers, Simon& Huppert, Julian Leon. 2010. A Toolbox for Predicting G-Quadruplex Formation and Stability. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-481188
Modern Language Association (MLA)
Wong, Han Min…[et al.]. A Toolbox for Predicting G-Quadruplex Formation and Stability. Journal of Nucleic Acids No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-481188
American Medical Association (AMA)
Wong, Han Min& Stegle, Oliver& Rodgers, Simon& Huppert, Julian Leon. A Toolbox for Predicting G-Quadruplex Formation and Stability. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-481188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481188