Multicenter Retrospective Analysis of the Effectiveness and Safety of Rituximab in Korean Patients with Refractory Systemic Lupus Erythematosus
Joint Authors
Park, Yong-Wook
Bang, So-Young
Kang, Young Mo
Choe, Jung-Yoon
Kim, Hyoun-Ah
Lee, Hye-Soon
Yoo, Dae-Hyun
Lee, Chang Keun
Park, Yong-Beom
Kim, Tae-Jong
Suh, Chang-Hee
Bae, Sang-Cheol
Chung, Won Tae
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
Although two recent randomized placebo-controlled trials of rituximab (RTX) failed to demonstrate efficacy in systemic lupus erythematosus (SLE), clinicians continue to use off-label RTX for cases refractory to current treatments.
We evaluated the effectiveness and safety of rituximab for patients with refractory SLE in Korea.
Methods.
We retrospectively analyzed multicenter patients treated with RTX in Korea.
Results.
39 SLE patients treated with RTX were included in the following manner: lupus nephritis 43.6%, hematologic 33.3%, arthritis 7.8%, myositis 7.8%, and others 7.7%.
All patients had responded poorly to at least one conventional immunosuppressive agent (mean 2.5 ± 1.1, cyclophosphamide 43.6%, mycophenolate mofetil 48.7%, and other drugs) before RTX.
Clinical improvements (complete or partial remission) occurred in patients with renal disease, hematologic disease, arthritis, myositis, and other manifestations at 6 months after RTX.
The SLEDAI score was significantly decreased from 10.8±7.1 at baseline to 6.7±4.0 at 6 months, 6.2±4.1 at 12 months, and 5.5±3.6 at 24 months after RTX (P<0.05).
Among 28 clinical responders, 4 patients experienced a relapse of disease at 25±4 months.
Infections were noted in 3 patients (7.7%).
Conclusion.
RTX could be an effective and relatively safe therapeutic option in patients with severe refractory SLE until novel B-cell depletion therapy is available.
American Psychological Association (APA)
Bang, So-Young& Lee, Chang Keun& Kang, Young Mo& Yoo, Dae-Hyun& Bae, Sang-Cheol& Lee, Hye-Soon…[et al.]. 2012. Multicenter Retrospective Analysis of the Effectiveness and Safety of Rituximab in Korean Patients with Refractory Systemic Lupus Erythematosus. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-481196
Modern Language Association (MLA)
Yoo, Dae-Hyun…[et al.]. Multicenter Retrospective Analysis of the Effectiveness and Safety of Rituximab in Korean Patients with Refractory Systemic Lupus Erythematosus. Autoimmune Diseases No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-481196
American Medical Association (AMA)
Bang, So-Young& Lee, Chang Keun& Kang, Young Mo& Yoo, Dae-Hyun& Bae, Sang-Cheol& Lee, Hye-Soon…[et al.]. Multicenter Retrospective Analysis of the Effectiveness and Safety of Rituximab in Korean Patients with Refractory Systemic Lupus Erythematosus. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-481196
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481196