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Stimulation of Perforant Path Fibers Induces LTP Concurrently in Amygdala and Hippocampus in Awake Freely Behaving Rats
Joint Authors
Blaise, J. Harry
Hartman, Rachel A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Long-term potentiation (LTP) which has long been considered a cellular model for learning and memory is defined as a lasting enhancement in synaptic transmission efficacy.
This cellular mechanism has been demonstrated reliably in the hippocampus and the amygdala—two limbic structures implicated in learning and memory.
Earlier studies reported on the ability of cortical stimulation of the entorhinal cortex to induce LTP simultaneously in the two sites.
However, to retain a stable baseline of comparison with the majority of the LTP literature, it is important to investigate the ability of fiber stimulation such as perforant path activation to induce LTP concurrently in both structures.
Therefore, in this paper we report on concurrent LTP in the basolateral amygdala (BLA) and the dentate gyrus (DG) subfield of the hippocampus induced by theta burst stimulation of perforant path fibers in freely behaving Sprague-Dawley rats.
Our results indicate that while perforant path-evoked potentials in both sites exhibit similar triphasic waveforms, the latency and amplitude of BLA responses were significantly shorter and smaller than those of DG.
In addition, we observed no significant differences in either the peak level or the duration of LTP between DG and BLA.
American Psychological Association (APA)
Blaise, J. Harry& Hartman, Rachel A.. 2013. Stimulation of Perforant Path Fibers Induces LTP Concurrently in Amygdala and Hippocampus in Awake Freely Behaving Rats. Neural Plasticity،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-481212
Modern Language Association (MLA)
Blaise, J. Harry& Hartman, Rachel A.. Stimulation of Perforant Path Fibers Induces LTP Concurrently in Amygdala and Hippocampus in Awake Freely Behaving Rats. Neural Plasticity No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-481212
American Medical Association (AMA)
Blaise, J. Harry& Hartman, Rachel A.. Stimulation of Perforant Path Fibers Induces LTP Concurrently in Amygdala and Hippocampus in Awake Freely Behaving Rats. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-481212
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481212