Long-Term Effect of an Aqueous Fraxinus excelsior L. Seed Extract in Spontaneously Hypertensive Rats
Joint Authors
Miguel, Marta
Aleixandre, Amaya
López-Carreras, Noemi
Fernández-Vallinas, Sandra
Source
International Journal of Hypertension
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The effect of long-term intake of different doses (20, 40, and 60 mg/kg/day) of a Fraxinus excelsior L.
seed extract (FESE) on spontaneously hypertensive rats (SHR) was evaluated.
Water was used as control and captopril (50 mg/kg/day) was used as positive control.
Systolic blood pressure, body weight, and food and liquid intake were registered weekly in SHR.
The antioxidant and vascular relaxing properties of FESE were also studied in these animals.
The development of hypertension was attenuated in the groups treated with captopril or FESE.
The antihypertensive effect was more accentuated in the captopril group than in the FESE groups, and it was paradoxically more accentuated in the groups treated with 20 mg/kg/day or 40 mg/kg/day of FESE than in the group treated with the highest dose of this extract.
Body weight gain and food intake increased in the FESE groups.
After removing the corresponding antihypertensive treatment, the arterial blood pressure and the body weight of the FESE treated animals returned to control values.
In addition, FESE increased plasma antioxidant capacity and decreased plasma and liver malondialdehyde levels.
Moreover, acetylcholine relaxation improved in the aorta rings from the FESE treated rats.
American Psychological Association (APA)
López-Carreras, Noemi& Fernández-Vallinas, Sandra& Miguel, Marta& Aleixandre, Amaya. 2014. Long-Term Effect of an Aqueous Fraxinus excelsior L. Seed Extract in Spontaneously Hypertensive Rats. International Journal of Hypertension،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-481215
Modern Language Association (MLA)
López-Carreras, Noemi…[et al.]. Long-Term Effect of an Aqueous Fraxinus excelsior L. Seed Extract in Spontaneously Hypertensive Rats. International Journal of Hypertension No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-481215
American Medical Association (AMA)
López-Carreras, Noemi& Fernández-Vallinas, Sandra& Miguel, Marta& Aleixandre, Amaya. Long-Term Effect of an Aqueous Fraxinus excelsior L. Seed Extract in Spontaneously Hypertensive Rats. International Journal of Hypertension. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-481215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481215