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Comparative Analysis of CpG Islands in Four Fish Genomes
Joint Authors
Source
Comparative and Functional Genomics
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-04-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
There has been much interest in CpG islands (CGIs), clusters of CpG dinucleotides in GC-rich regions, because they are considered gene markers and involved in gene regulation.
To date, there has been no genome-wide analysis of CGIs in the fish genome.
We first evaluated the performance of three popular CGI identification algorithms in four fish genomes (tetraodon, stickleback, medaka, and zebrafish).
Our results suggest that Takai and Jones' (2002) algorithm is most suitable for comparative analysis of CGIs in the fish genome.
Then, we performed a systematic analysis of CGIs in the four fish genomes using Takai and Jones' algorithm, compared to other vertebrate genomes.
We found that both the number of CGIs and the CGI density vary greatly among these genomes.
Remarkably, each fish genome presents a distinct distribution of CGI density with some genomic factors (e.g., chromosome size and chromosome GC content).
These findings are helpful for understanding evolution of fish genomes and the features of fish CGIs.
American Psychological Association (APA)
Han, Leng& Zhao, Zhongming. 2008. Comparative Analysis of CpG Islands in Four Fish Genomes. Comparative and Functional Genomics،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-481240
Modern Language Association (MLA)
Han, Leng& Zhao, Zhongming. Comparative Analysis of CpG Islands in Four Fish Genomes. Comparative and Functional Genomics No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-481240
American Medical Association (AMA)
Han, Leng& Zhao, Zhongming. Comparative Analysis of CpG Islands in Four Fish Genomes. Comparative and Functional Genomics. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-481240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481240