Involvement of F-Actin in Chaperonin-Containing t-Complex 1 Beta Regulating Mouse Mesangial Cell Functions in a Glucose-Induction Cell Model
Joint Authors
Wu, Chia-Chao
Chen, Jin-Shuen
Lin, Yuh-Feng
Yeung, Lai-King
Chang, Li-Chien
Source
Experimental Diabetes Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of this study is to investigate the role of chaperonin-containing t-complex polypeptide 1 beta (CCT2) in the regulation of mouse mesangial cell (mMC) contraction, proliferation, and migration with filamentous/globular-(F/G-) actin ratio under high glucose induction.
A low CCT2 mMC model induced by treatment of small interference RNA was established.
Groups with and without low CCT2 induction examined in normal and high (H) glucose conditions revealed the following major results: (1) low CCT2 or H glucose showed the ability to attenuate F/G-actin ratio; (2) groups with low F/G-actin ratio all showed less cell contraction; (3) suppression of CCT2 may reduce the proliferation and migration which were originally induced by H glucose.
In conclusion, CCT2 can be used as a specific regulator for mMC contraction, proliferation, and migration affected by glucose, which mechanism may involve the alteration of F-actin, particularly for cell contraction.
American Psychological Association (APA)
Chen, Jin-Shuen& Chang, Li-Chien& Wu, Chia-Chao& Yeung, Lai-King& Lin, Yuh-Feng. 2011. Involvement of F-Actin in Chaperonin-Containing t-Complex 1 Beta Regulating Mouse Mesangial Cell Functions in a Glucose-Induction Cell Model. Experimental Diabetes Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-481243
Modern Language Association (MLA)
Chen, Jin-Shuen…[et al.]. Involvement of F-Actin in Chaperonin-Containing t-Complex 1 Beta Regulating Mouse Mesangial Cell Functions in a Glucose-Induction Cell Model. Experimental Diabetes Research No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-481243
American Medical Association (AMA)
Chen, Jin-Shuen& Chang, Li-Chien& Wu, Chia-Chao& Yeung, Lai-King& Lin, Yuh-Feng. Involvement of F-Actin in Chaperonin-Containing t-Complex 1 Beta Regulating Mouse Mesangial Cell Functions in a Glucose-Induction Cell Model. Experimental Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-481243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481243