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Early Focal Segmental Glomerulosclerosis as a Cause of Renal Allograft Primary Nonfunction
Joint Authors
Griffin, Emma J.
Clancy, Marc
Thomson, Peter C.
Kipgen, David
Daly, Conal
Source
Case Reports in Transplantation
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-23
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Primary focal segmental glomerulosclerosis (FSGS) is one of the commonest causes of glomerular disease and if left untreated will often progress to established renal failure.
In many cases the best treatment option is renal transplantation; however primary FSGS may rapidly recur in renal allografts and may contribute to delayed graft function.
We present a case of primary nonfunction in a renal allograft due to biopsy-proven FSGS.
Case Report.
A 32-year-old man presented with serum albumin of 22 g/L, proteinuria quantified at 12 g/L, and marked peripheral oedema.
Renal biopsy demonstrated tip-variant FSGS.
Despite treatment, the patient developed progressive renal dysfunction and was commenced on haemodialysis.
Cadaveric renal transplantation was undertaken; however this was complicated by primary nonfunction.
Renal biopsies failed to demonstrate evidence of acute rejection but did demonstrate clear evidence of FSGS.
The patient was treated to no avail.
Discussion.
Primary renal allograft nonfunction following transplantation is often due to acute kidney injury or acute rejection.
Recurrent FSGS is recognised as a phenomenon that drives allograft dysfunction but is not traditionally associated with primary nonfunction.
This case highlights FSGS as a potentially aggressive process that, once active in the allograft, may prove refractory to targeted treatment.
Preemptive therapies in patients deemed to be at high risk of recurrent disease may be appropriate and should be considered.
American Psychological Association (APA)
Griffin, Emma J.& Thomson, Peter C.& Kipgen, David& Clancy, Marc& Daly, Conal. 2013. Early Focal Segmental Glomerulosclerosis as a Cause of Renal Allograft Primary Nonfunction. Case Reports in Transplantation،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-481246
Modern Language Association (MLA)
Griffin, Emma J.…[et al.]. Early Focal Segmental Glomerulosclerosis as a Cause of Renal Allograft Primary Nonfunction. Case Reports in Transplantation No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-481246
American Medical Association (AMA)
Griffin, Emma J.& Thomson, Peter C.& Kipgen, David& Clancy, Marc& Daly, Conal. Early Focal Segmental Glomerulosclerosis as a Cause of Renal Allograft Primary Nonfunction. Case Reports in Transplantation. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-481246
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481246