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Jiao Tai Wan Attenuates Hepatic Lipid Accumulation in Type 2 Diabetes Mellitus
Joint Authors
Chen, Guang
Lu, Fuer
Wang, Nan
Xu, Lijun
Xu, Xiaohu
Wang, Kaifu
Zou, Xin
Huang, Zhaoyi
Zhao, Yan
Dong, Hui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Jiao Tai Wan (JTW), a Chinese herbal formula containing Rhizoma Coptidis and Cortex Cinnamomi, has been used for diabetic treatment for many years.
The aim of this study was to determine the main components in JTW and to investigate the effects of JTW on hepatic lipid accumulation in diabetic rats and humans.
JTW extract was prepared and the main components were assayed by HPLC.
An animal model of diabetes mellitus was established and JTW was administered intragastrically.
In the clinical study, diabetic patients with poor glycemic control were treated with JTW.
Blood glucose and lipid parameters, liver histology, hepatic triglyceride content and lipogenic gene expression were examined.
Our data demonstrated that JTW significantly improved hyperglycemia, hyperlipidemia and hepatic lipid accumulation in diabetic rats.
This was accompanied by the down-regulation of acetyl coenzyme A carboxylase (ACC) and fatty acid synthase (FAS) protein expressions, and the up-regulation of AMP-activated protein kinase (AMPK) and phosphorylated-ACC (pACC) protein expressions in the liver tissues.
Diabetic patients also exhibited decreases in their hepatic triglyceride content.
The results suggest that JTW attenuates hepatic lipid accumulation in diabetic rats and humans.
These beneficial effects are possibly associated with the inhibition of lipogenic gene expression in the liver.
American Psychological Association (APA)
Huang, Zhaoyi& Xu, Xiaohu& Lu, Fuer& Wang, Nan& Chen, Guang& Zhao, Yan…[et al.]. 2013. Jiao Tai Wan Attenuates Hepatic Lipid Accumulation in Type 2 Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-481266
Modern Language Association (MLA)
Huang, Zhaoyi…[et al.]. Jiao Tai Wan Attenuates Hepatic Lipid Accumulation in Type 2 Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-481266
American Medical Association (AMA)
Huang, Zhaoyi& Xu, Xiaohu& Lu, Fuer& Wang, Nan& Chen, Guang& Zhao, Yan…[et al.]. Jiao Tai Wan Attenuates Hepatic Lipid Accumulation in Type 2 Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-481266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481266