Gram-Negative Bacterial Infection in Thigh Abscess Can Migrate to Distant Burn Depending on Burn Depth
Joint Authors
Fischman, Alan J.
Hamrahi, Victoria
Carter, Edward A.
Benjamin, John B.
Hamblin, Michael R.
Tompkins, Ronald G.
Dantas, Jung Siung Camel
Paul, Kasie W.
Source
Interdisciplinary Perspectives on Infectious Diseases
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Sepsis remains the major cause of death in patients with major burn injuries.
In the present investigation we evaluated the interaction between burn injuries of varying severity and preexisting distant infection.
We used Gram-negative bacteria (Pseudomonas aeruginosa and Proteus mirabilis) that were genetically engineered to be bioluminescent, which allowed for noninvasive, sequential optical imaging of the extent and severity of the infection.
The bioluminescent bacteria migrated from subcutaneous abscesses in the leg to distant burn wounds on the back depending on the severity of the burn injury, and this migration led to increased mortality of the mice.
Treatment with ciprofloxacin, injected either in the leg with the bacterial infection or into the burn eschar, prevented this colonization of the wound and decreased mortality.
The present data suggest that burn wounds can readily become colonized by infections distant from the wound itself.
American Psychological Association (APA)
Hamrahi, Victoria& Hamblin, Michael R.& Dantas, Jung Siung Camel& Benjamin, John B.& Paul, Kasie W.& Fischman, Alan J.…[et al.]. 2012. Gram-Negative Bacterial Infection in Thigh Abscess Can Migrate to Distant Burn Depending on Burn Depth. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-481278
Modern Language Association (MLA)
Hamrahi, Victoria…[et al.]. Gram-Negative Bacterial Infection in Thigh Abscess Can Migrate to Distant Burn Depending on Burn Depth. Interdisciplinary Perspectives on Infectious Diseases No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-481278
American Medical Association (AMA)
Hamrahi, Victoria& Hamblin, Michael R.& Dantas, Jung Siung Camel& Benjamin, John B.& Paul, Kasie W.& Fischman, Alan J.…[et al.]. Gram-Negative Bacterial Infection in Thigh Abscess Can Migrate to Distant Burn Depending on Burn Depth. Interdisciplinary Perspectives on Infectious Diseases. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-481278
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481278