Type I IL-1 Receptor (IL-1RI) as Potential New Therapeutic Target for Bronchial Asthma
Joint Authors
Yu, Hsin-Hui
Yang, Yao-Hsu
Wang, Li-Chieh
Chiang, Bor-Luen
Lee, Jyh-Hong
Lin, Yu-Tsan
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The IL-1R/TLR family has been receiving considerable attention as potential regulators of inflammation through their ability to act as either activators or suppressors of inflammation.
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness, allergic inflammation, elevated serum total, allergen-specific IgE levels, and increased Th2 cytokine production.
The discovery that the IL-1RI–IL-1 and ST2–IL-33 pathways are crucial for allergic inflammation has raised interest in these receptors as potential targets for developing new therapeutic strategies for bronchial asthma.
This paper discusses the current use of neutralizing mAb or soluble receptor constructs to deplete cytokines, the use of neutralizing mAb or recombinant receptor antagonists to block cytokine receptors, and gene therapy from experimental studies in asthma.
Targeting IL-1RI–IL-1 as well as ST2–IL-33 pathways may promise a disease-modifying approach in the future.
American Psychological Association (APA)
Lee, Jyh-Hong& Wang, Li-Chieh& Yu, Hsin-Hui& Lin, Yu-Tsan& Yang, Yao-Hsu& Chiang, Bor-Luen. 2010. Type I IL-1 Receptor (IL-1RI) as Potential New Therapeutic Target for Bronchial Asthma. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-481307
Modern Language Association (MLA)
Lee, Jyh-Hong…[et al.]. Type I IL-1 Receptor (IL-1RI) as Potential New Therapeutic Target for Bronchial Asthma. Mediators of Inflammation No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-481307
American Medical Association (AMA)
Lee, Jyh-Hong& Wang, Li-Chieh& Yu, Hsin-Hui& Lin, Yu-Tsan& Yang, Yao-Hsu& Chiang, Bor-Luen. Type I IL-1 Receptor (IL-1RI) as Potential New Therapeutic Target for Bronchial Asthma. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-481307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481307