Type I IL-1 Receptor (IL-1RI)‎ as Potential New Therapeutic Target for Bronchial Asthma

Joint Authors

Yu, Hsin-Hui
Yang, Yao-Hsu
Wang, Li-Chieh
Chiang, Bor-Luen
Lee, Jyh-Hong
Lin, Yu-Tsan

Source

Mediators of Inflammation

Issue

Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2010-07-05

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases

Abstract EN

The IL-1R/TLR family has been receiving considerable attention as potential regulators of inflammation through their ability to act as either activators or suppressors of inflammation.

Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness, allergic inflammation, elevated serum total, allergen-specific IgE levels, and increased Th2 cytokine production.

The discovery that the IL-1RI–IL-1 and ST2–IL-33 pathways are crucial for allergic inflammation has raised interest in these receptors as potential targets for developing new therapeutic strategies for bronchial asthma.

This paper discusses the current use of neutralizing mAb or soluble receptor constructs to deplete cytokines, the use of neutralizing mAb or recombinant receptor antagonists to block cytokine receptors, and gene therapy from experimental studies in asthma.

Targeting IL-1RI–IL-1 as well as ST2–IL-33 pathways may promise a disease-modifying approach in the future.

American Psychological Association (APA)

Lee, Jyh-Hong& Wang, Li-Chieh& Yu, Hsin-Hui& Lin, Yu-Tsan& Yang, Yao-Hsu& Chiang, Bor-Luen. 2010. Type I IL-1 Receptor (IL-1RI) as Potential New Therapeutic Target for Bronchial Asthma. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-481307

Modern Language Association (MLA)

Lee, Jyh-Hong…[et al.]. Type I IL-1 Receptor (IL-1RI) as Potential New Therapeutic Target for Bronchial Asthma. Mediators of Inflammation No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-481307

American Medical Association (AMA)

Lee, Jyh-Hong& Wang, Li-Chieh& Yu, Hsin-Hui& Lin, Yu-Tsan& Yang, Yao-Hsu& Chiang, Bor-Luen. Type I IL-1 Receptor (IL-1RI) as Potential New Therapeutic Target for Bronchial Asthma. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-481307

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-481307