IGF-1 Increases with Hyperbaric Oxygen Therapy and Promotes Wound Healing in Diabetic Foot Ulcers

Abstract EN

Objectives.

To investigate insulin-like growth factor I (IGF-1) levels in response to hyperbaric oxygen therapy (HBOT) for diabetic foot ulcers and to determine whether IGF-1 is a predictive indicator of wound healing in patients with diabetic foot ulcers.

Design and Methods.

We treated 48 consecutive patients with diabetic foot ulcers with HBOT.

Alterations of IGF-1 levels in patients whose wound healed with HBOT were compared with those in patients who did not benefit from HBOT.

Results.

There was no significant difference in initial IGF-1 levels between the two groups (P=0.399).

The mean IGF-1 level increased with HBOT (P<0.05).

In the healed group, the mean IGF-1 increase and the final values were significantly higher (P<0.05).

In the nonhealed group, the mean IGF-1 increase was minus and the final values were not significantly different (P<0.05).

The increase in IGF-1 level with HBOT was significantly higher in the healed group (P<0.001).

Conclusions.

IGF-1 increased significantly in the healed group.

We believe that HBOT is effective in the treatment of diabetic foot ulcers, with an elevation of IGF-1.

This alteration seems to be a predictive factor for wound healing in diabetic foot ulcers treated with HBOT.