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The Mysterious Unfoldome : Structureless, Underappreciated, Yet Vital Part of Any Given Proteome
Author
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-25
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Contrarily to the general believe, many biologically active proteins lack stable tertiary and/or secondary structure under physiological conditions in vitro.
These intrinsically disordered proteins (IDPs) are highly abundant in nature and many of them are associated with various human diseases.
The functional repertoire of IDPs complements the functions of ordered proteins.
Since IDPs constitute a significant portion of any given proteome, they can be combined in an unfoldome; which is a portion of the proteome including all IDPs (also known as natively unfolded proteins, therefore, unfoldome), and describing their functions, structures, interactions, evolution, and so forth.
Amino acid sequence and compositions of IDPs are very different from those of ordered proteins, making possible reliable identification of IDPs at the proteome level by various computational means.
Furthermore, IDPs possess a number of unique structural properties and are characterized by a peculiar conformational behavior, including their high stability against low pH and high temperature and their structural indifference toward the unfolding by strong denaturants.
These peculiarities were shown to be useful for elaboration of the experimental techniques for the large-scale identification of IDPs in various organisms.
Some of the computational and experimental tools for the unfoldome discovery are discussed in this review.
American Psychological Association (APA)
Uversky, Vladimir N.. 2009. The Mysterious Unfoldome : Structureless, Underappreciated, Yet Vital Part of Any Given Proteome. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-481361
Modern Language Association (MLA)
Uversky, Vladimir N.. The Mysterious Unfoldome : Structureless, Underappreciated, Yet Vital Part of Any Given Proteome. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-481361
American Medical Association (AMA)
Uversky, Vladimir N.. The Mysterious Unfoldome : Structureless, Underappreciated, Yet Vital Part of Any Given Proteome. Journal of Biomedicine and Biotechnology. 2009. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-481361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481361