Neuroprotection and Neurodegeneration in Alzheimer’s Disease : Role of Cardiovascular Disease Risk Factors, Implications for Dementia Rates, and Prevention with Aerobic Exercise in African Americans
Joint Authors
Bond, Vernon
Obisesan, Thomas O.
Gillum, Richard F.
Umar, Nisser
Johnson, Stephanie
Williams, Deborah
Kwagyan, John
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-17
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Prevalence of Alzheimer’s disease (AD) will reach epidemic proportions in the United States and worldwide in the coming decades, and with substantially higher rates in African Americans (AAs) than in Whites.
Older age, family history, low levels of education, and ɛ4 allele of the apolipoprotein E (APOE) gene are recognized risk factors for the neurodegeneration in AD and related disorders.
In AAs, the contributions of APOE gene to AD risk continue to engender a considerable debate.
In addition to the established role of cardiovascular disease (CVD) risk in vascular dementia, it is now believed that CVD risk and its endophenotype may directly comediate AD phenotype.
Given the pleiotropic effects of APOE on CVD and AD risks, the higher rates of CVD risks in AAs than in Whites, it is likely that CVD risks contribute to the disproportionately higher rates of AD in AAs.
Though the advantageous effects of aerobic exercise on cognition is increasingly recognized, this evidence is hardly definitive, and data on AAs is lacking.
In this paper, we will discuss the roles of CVD risk factors in the development of AD and related dementias, the susceptibility of these risk factors to physiologic adaptation, and fitness-related improvements in cognitive function.
Its relevance to AD prevention in AAs is emphasized.
American Psychological Association (APA)
Obisesan, Thomas O.& Gillum, Richard F.& Johnson, Stephanie& Umar, Nisser& Williams, Deborah& Bond, Vernon…[et al.]. 2012. Neuroprotection and Neurodegeneration in Alzheimer’s Disease : Role of Cardiovascular Disease Risk Factors, Implications for Dementia Rates, and Prevention with Aerobic Exercise in African Americans. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-481402
Modern Language Association (MLA)
Obisesan, Thomas O.…[et al.]. Neuroprotection and Neurodegeneration in Alzheimer’s Disease : Role of Cardiovascular Disease Risk Factors, Implications for Dementia Rates, and Prevention with Aerobic Exercise in African Americans. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-481402
American Medical Association (AMA)
Obisesan, Thomas O.& Gillum, Richard F.& Johnson, Stephanie& Umar, Nisser& Williams, Deborah& Bond, Vernon…[et al.]. Neuroprotection and Neurodegeneration in Alzheimer’s Disease : Role of Cardiovascular Disease Risk Factors, Implications for Dementia Rates, and Prevention with Aerobic Exercise in African Americans. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-481402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481402