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Synthesis, Structural Characterization, and Biological Activity Studies of Ni(II) and Zn(II) Complexes
Joint Authors
Laxma Reddy, K.
Kavitha, Palakuri
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Ni(II) and Zn(II) complexes were synthesized from tridentate 3-formyl chromone Schiff bases such as 3-((2-hydroxyphenylimino)methyl)-4H-chromen-4-one (HL1), 2-((4-oxo-4H-chromen-3-yl)methylneamino)benzoic acid (HL2), 3-((3-hydroxypyridin-2-ylimino)methyl)-4H-chromen-4-one (HL3), and 3-((2-mercaptophenylimino)methyl)-4H-chromen-4-one (HL4).
All the complexes were characterized in the light of elemental analysis, molar conductance, FTIR, UV-VIS, magnetic, thermal, powder XRD, and SEM studies.
The conductance and spectroscopic data suggested that, the ligands act as neutral and monobasic tridentate ligands and form octahedral complexes with general formula [M(L1–4)2]·nH2O (M = Ni(II) and Zn(II)).
Metal complexes exhibited pronounced activity against tested bacteria and fungi strains compared to the ligands.
In addition metal complexes displayed good antioxidant and moderate nematicidal activities.
The cytotoxicity of ligands and their metal complexes have been evaluated by MTT assay.
The DNA cleavage activity of the metal complexes was performed using agarose gel electrophoresis in the presence and absence of oxidant H2O2.
All metal complexes showed significant nuclease activity in the presence of H2O2.
American Psychological Association (APA)
Kavitha, Palakuri& Laxma Reddy, K.. 2014. Synthesis, Structural Characterization, and Biological Activity Studies of Ni(II) and Zn(II) Complexes. Bioinorganic Chemistry and Applications،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-481431
Modern Language Association (MLA)
Kavitha, Palakuri& Laxma Reddy, K.. Synthesis, Structural Characterization, and Biological Activity Studies of Ni(II) and Zn(II) Complexes. Bioinorganic Chemistry and Applications No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-481431
American Medical Association (AMA)
Kavitha, Palakuri& Laxma Reddy, K.. Synthesis, Structural Characterization, and Biological Activity Studies of Ni(II) and Zn(II) Complexes. Bioinorganic Chemistry and Applications. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-481431
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481431