![](/images/graphics-bg.png)
Iminoflavones Combat 1,2-Dimethyl Hydrazine-Induced Aberrant Crypt Foci Development in Colon Cancer
Joint Authors
Kawade, Shishir
Prasad, V. Ganga
Shenoy, Rekha R.
Reddy, Neetinkumar D.
Rao, C. Mallikarjuna
Kishore, Anoop
Nayak, Pawan G.
Nandakumar, K.
Jayashree, B. S.
Francis, Albi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of the present study was to evaluate the antitumor potential of iminoflavones in in vitro and in vivo anticancer models.
Preliminary screening in various cancer cell lines revealed four potential iminoflavones out of which IMF-8 was taken based on its activity against colon cancer cells.
This was further confirmed by observing the nuclear changes in the cells by AO/EB and Hoechst 33342 staining studies.
In vivo activity was assessed by dimethyl hydrazine-(DMH-) induced colon cancer model in rats.
Animals were administered DMH (20 mg/kg, b.w.
for 10 weeks and 30 mg/kg b.w., i.p.
for 10 weeks) and were supplemented with (IMF-8) iminoflavone-8 (200 mg/kg, p.o.
for 14 days).
Results showed that DMH induced 100% aberrant crypt foci (ACF) and polyps which were significantly reduced in the IMF-8 treated group.
IMF-8 significantly increased the catalase and GSH levels whereas it reduced the TNF-α and IL-6 levels markedly which suggests the antioxidative and anti-inflammatory actions of flavonoids present in IMF-8.
The histopathological images of the IMF-8 treated colon showed no signs of mucosal crypt abscess.
These findings suggest that the semi-synthetic iminoflavones, IMF-8, effectively inhibit DMH-induced ACFs and colonic crypts by alleviating the oxidative stress and suppressing the inflammation.
American Psychological Association (APA)
Prasad, V. Ganga& Kawade, Shishir& Jayashree, B. S.& Reddy, Neetinkumar D.& Francis, Albi& Nayak, Pawan G.…[et al.]. 2014. Iminoflavones Combat 1,2-Dimethyl Hydrazine-Induced Aberrant Crypt Foci Development in Colon Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-481466
Modern Language Association (MLA)
Prasad, V. Ganga…[et al.]. Iminoflavones Combat 1,2-Dimethyl Hydrazine-Induced Aberrant Crypt Foci Development in Colon Cancer. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-481466
American Medical Association (AMA)
Prasad, V. Ganga& Kawade, Shishir& Jayashree, B. S.& Reddy, Neetinkumar D.& Francis, Albi& Nayak, Pawan G.…[et al.]. Iminoflavones Combat 1,2-Dimethyl Hydrazine-Induced Aberrant Crypt Foci Development in Colon Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-481466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481466