Retinal Nerve Fiber Layer Decrease during Glycemic Control in Type 2 Diabetes

Abstract EN

Purpose.

To assess an effect of glycemic control on retinal nerve fiber layer (RNFL) in type 2 diabetes mellitus.

Methods.

Thirty-eight eyes of 38 patients with type 2 diabetes undergoing blood glucose regulation were enrolled.

All patients were examined at (1) initial visit, (2) 1 month, (3) 2 months, and (4) 4-month after the initial examination.

On each occasion, glycosylated hemoglobin (HbA1c) levels and optical coherence tomography (OCT) scanning for RNFL thickness were evaluated.

360 degree circular OCT scans with a diameter of 3.4 mm centered on the optic disc were performed.

Results.

Significant RNFL decrease was seen in the superior area between initial and 4 months examination (P=.043).

The relationship between the changes in HbA1c and the changes in RNFL thickness was observed in superior, temporal, and inferior area (P<.05) at 4 months.

Conclusions.

This study suggests that the glycemic control affects RNFL within 4 months.