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Cardiac Response to Chronic Intermittent Hypoxia with a Transition from Adaptation to Maladaptation : The Role of Hydrogen Peroxide
Joint Authors
Cai, Lu
Yin, Xia
Zheng, Yang
Cai, Jun
Liu, Quan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Obstructive sleep apnea (OSA) is a highly prevalent respiratory disorder of sleep, and associated with chronic intermittent hypoxia (CIH).
Experimental evidence indicates that CIH is a unique physiological state with potentially “adaptive” and “maladaptive” consequences for cardio-respiratory homeostasis.
CIH is also a critical element accounting for most of cardiovascular complications of OSA.
Cardiac response to CIH is time-dependent, showing a transition from cardiac compensative (such as hypertrophy) to decompensating changes (such as failure).
CIH-provoked mild and transient oxidative stress can induce adaptation, but severe and persistent oxidative stress may provoke maladaptation.
Hydrogen peroxide as one of major reactive oxygen species plays an important role in the transition of adaptive to maladaptive response to OSA-associated CIH.
This may account for the fact that although oxidative stress has been recognized as a driver of cardiac disease progression, clinical interventions with antioxidants have had little or no impact on heart disease and progression.
Here we focus on the role of hydrogen peroxide in CIH and OSA, trying to outline the potential of antioxidative therapy in preventing CIH-induced cardiac damage.
American Psychological Association (APA)
Yin, Xia& Zheng, Yang& Liu, Quan& Cai, Jun& Cai, Lu. 2012. Cardiac Response to Chronic Intermittent Hypoxia with a Transition from Adaptation to Maladaptation : The Role of Hydrogen Peroxide. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-481503
Modern Language Association (MLA)
Yin, Xia…[et al.]. Cardiac Response to Chronic Intermittent Hypoxia with a Transition from Adaptation to Maladaptation : The Role of Hydrogen Peroxide. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-481503
American Medical Association (AMA)
Yin, Xia& Zheng, Yang& Liu, Quan& Cai, Jun& Cai, Lu. Cardiac Response to Chronic Intermittent Hypoxia with a Transition from Adaptation to Maladaptation : The Role of Hydrogen Peroxide. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-481503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481503