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Oxidative Stress and Bone Resorption Interplay as a Possible Trigger for Postmenopausal Osteoporosis
Joint Authors
Cremonini, Eleonora
Romani, Arianna
Bonaccorsi, Gloria
Ferrazzini, Stefania
Massari, Leo
Fila, Enrica
Cervellati, Carlo
Giganti, Melchiorre
Castaldini, Maria Cristina
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The underlying mechanism in postmenopausal osteoporosis (PO) is an imbalance between bone resorption and formation.
This study was conducted to investigate whether oxidative stress (OxS) might have a role in this derangement of bone homeostasis.
In a sample of 167 postmenopausal women, we found that increased serum levels of a lipid peroxidation marker, hydroperoxides, were negatively and independently associated with decreased bone mineral density (BMD) in total body (r=-0.192, P<0.05), lumbar spine (r=-0.282, P<0.01), and total hip (r=-0.282, P<0.05), as well as with increased bone resorption rate (r=0.233, P<0.05), as assessed by the serum concentration of C-terminal telopeptide of type I collagen (CTX-1).
On the contrary, the OxS marker failed to be correlated with the serum levels of bone-specific alkaline phosphatase (BAP), that is, elective marker of bone formation.
Importantly, multiple regression analysis revealed that hydroperoxides is a determinant factor for the statistical association between lumbar spine BMD and CTX-1 levels.
Taken together, our data suggest that OxS might mediate, by enhancing bone resorption, the uncoupling of bone turnover that underlies PO development.
American Psychological Association (APA)
Cervellati, Carlo& Bonaccorsi, Gloria& Cremonini, Eleonora& Romani, Arianna& Fila, Enrica& Castaldini, Maria Cristina…[et al.]. 2014. Oxidative Stress and Bone Resorption Interplay as a Possible Trigger for Postmenopausal Osteoporosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-481507
Modern Language Association (MLA)
Cervellati, Carlo…[et al.]. Oxidative Stress and Bone Resorption Interplay as a Possible Trigger for Postmenopausal Osteoporosis. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-481507
American Medical Association (AMA)
Cervellati, Carlo& Bonaccorsi, Gloria& Cremonini, Eleonora& Romani, Arianna& Fila, Enrica& Castaldini, Maria Cristina…[et al.]. Oxidative Stress and Bone Resorption Interplay as a Possible Trigger for Postmenopausal Osteoporosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-481507
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481507