Malignant Mixed Mullerian Tumor : An Immunohistochemical Study
Joint Authors
Bing, Zhanyong
Zhang, Paul J.
Wang, Li-Ping
Pasha, Theresa
Source
Pathology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Malignant mixed Mullerian tumor (MMMT) is an uncommon aggressive neoplasm composed of both malignant epithelial and mesenchymal components.
In this study, immunohistochemical stains of germ cell markers, including SALL4, OCT3/4, glypican-3, and alpha-fetal protein (AFP), and CDX2 were performed in a series of MMMTs.
SALL4 nuclear immunoreactivity was detected in 6 out of 19 cases (33%).
The staining extent ranged from focal to extensive.
The staining intensity was usually intermediate to strong (the score ranged from 1.5 to 3, and average score was 2.3 ± 0.5 in the positive cases).
In addition, glypican-3 cytoplasmic reactivity was detected in 14 out of 16 cases (88%) with a mean score of 1.8 ± 0.7 (score ranging from 1 to 3).
In contrast, OCT3/4 was only positive in 1 out of 19 cases and AFP in 2 out of 18 cases (11%).
In summary, SALL4 and glypican-3 were frequently expressed in a subset of MMMTs.
Their roles in the pathogenesis and biology of MMMT are yet to be determined.
MMMT should be included in the differential diagnosis when a tumor is positive for SALL4 and/or glypican-3.
American Psychological Association (APA)
Bing, Zhanyong& Pasha, Theresa& Wang, Li-Ping& Zhang, Paul J.. 2012. Malignant Mixed Mullerian Tumor : An Immunohistochemical Study. Pathology Research International،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-481513
Modern Language Association (MLA)
Bing, Zhanyong…[et al.]. Malignant Mixed Mullerian Tumor : An Immunohistochemical Study. Pathology Research International No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-481513
American Medical Association (AMA)
Bing, Zhanyong& Pasha, Theresa& Wang, Li-Ping& Zhang, Paul J.. Malignant Mixed Mullerian Tumor : An Immunohistochemical Study. Pathology Research International. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-481513
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481513