Variability in Myosteatosis and Insulin Resistance Induced by High-Fat Diet in Mouse Skeletal Muscles
Joint Authors
Collino, Massimo
Minetto, Marco Alessandro
Mastrocola, Raffaella
D’Antona, Giuseppe
Nigro, Debora
Chiazza, Fausto
Aragno, Manuela
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Nutrient overload leads to impaired muscle oxidative capacity and insulin sensitivity.
However, comparative analyses of the effects of dietary manipulation on skeletal muscles with different fiber composition are lacking.
This study aimed to investigate the selective adaptations in the soleus and tibialis anterior muscles evoked by administration of high-fat diet for 12 weeks in 10 mice (HFD mice) compared to 10 animals fed with a normal chow diet (control mice).
Mice fed with the HFD diet exhibited hyperlipidemia, hyperinsulinemia, hyperglycemia, and lower exercise capacity in comparison to control mice.
In control mice, soleus fibers showed higher lipid content than tibialis anterior fibers.
In contrast, the lipid content was similar between the two muscles in HFD mice.
Significant differences in markers of muscle mitochondrial production and/or activity as well as of lipid synthesis were detected between HFD mice and control mice, especially in the tibialis anterior.
Moreover, translocation of GLUT-4 transporter to the plasma membrane and activation of the insulin signaling pathway were markedly inhibited in the tibialis and slightly reduced in the soleus of HFD mice compared to control mice.
Overall, these results show that adaptive responses to dietary manipulation occur in a muscle-specific pattern.
American Psychological Association (APA)
Collino, Massimo& Mastrocola, Raffaella& Nigro, Debora& Chiazza, Fausto& Aragno, Manuela& D’Antona, Giuseppe…[et al.]. 2014. Variability in Myosteatosis and Insulin Resistance Induced by High-Fat Diet in Mouse Skeletal Muscles. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-481514
Modern Language Association (MLA)
Collino, Massimo…[et al.]. Variability in Myosteatosis and Insulin Resistance Induced by High-Fat Diet in Mouse Skeletal Muscles. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-481514
American Medical Association (AMA)
Collino, Massimo& Mastrocola, Raffaella& Nigro, Debora& Chiazza, Fausto& Aragno, Manuela& D’Antona, Giuseppe…[et al.]. Variability in Myosteatosis and Insulin Resistance Induced by High-Fat Diet in Mouse Skeletal Muscles. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-481514
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481514