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The Landscape of Protein Biomarkers Proposed for Periodontal Disease : Markers with Functional Meaning
Joint Authors
Barros, Marlene
Rosa, Nuno
Costa, Nuno
Correia, Maria José
Arrais, Joel P.
Oliveira, José Luís
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-26
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Periodontal disease (PD) is characterized by a deregulated inflammatory response which fails to resolve, activating bone resorption.
The identification of the proteomes associated with PD has fuelled biomarker proposals; nevertheless, many questions remain.
Biomarker selection should favour molecules representing an event which occurs throughout the disease progress.
The analysis of proteome results and the information available for each protein, including its functional role, was accomplished using the OralOme database.
The integrated analysis of this information ascertains if the suggested proteins reflect the cell and/or molecular mechanisms underlying the different forms of periodontal disease.
The evaluation of the proteins present/absent or with very different concentrations in the proteome of each disease state was used for the identification of the mechanisms shared by different PD variants or specific to such state.
The information presented is relevant for the adequate design of biomarker panels for PD.
Furthermore, it will open new perspectives and help envisage future studies targeted to unveil the functional role of specific proteins and help clarify the deregulation process in the PD inflammatory response.
American Psychological Association (APA)
Rosa, Nuno& Correia, Maria José& Arrais, Joel P.& Costa, Nuno& Oliveira, José Luís& Barros, Marlene. 2014. The Landscape of Protein Biomarkers Proposed for Periodontal Disease : Markers with Functional Meaning. BioMed Research International،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-481516
Modern Language Association (MLA)
Rosa, Nuno…[et al.]. The Landscape of Protein Biomarkers Proposed for Periodontal Disease : Markers with Functional Meaning. BioMed Research International No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-481516
American Medical Association (AMA)
Rosa, Nuno& Correia, Maria José& Arrais, Joel P.& Costa, Nuno& Oliveira, José Luís& Barros, Marlene. The Landscape of Protein Biomarkers Proposed for Periodontal Disease : Markers with Functional Meaning. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-481516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481516