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Hyperglycemia and Endothelial Dysfunction in Atherosclerosis : Lessons from Type 1 Diabetes
Joint Authors
Orr, A. Wayne
Yurdagul, Arif
Funk, Steven Daniel
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-14
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
A clear relationship between diabetes and cardiovascular disease has been established for decades.
Despite this, the mechanisms by which diabetes contributes to plaque formation remain in question.
Some of this confusion derives from studies in type 2 diabetics where multiple components of metabolic syndrome show proatherosclerotic effects independent of underlying diabetes.
However, the hyperglycemia that defines the diabetic condition independently affects atherogenesis in cell culture systems, animal models, and human patients.
Endothelial cell biology plays a central role in atherosclerotic plaque formation regulating vessel permeability, inflammation, and thrombosis.
The current paper highlights the mechanisms by which hyperglycemia affects endothelial cell biology to promote plaque formation.
American Psychological Association (APA)
Funk, Steven Daniel& Yurdagul, Arif& Orr, A. Wayne. 2012. Hyperglycemia and Endothelial Dysfunction in Atherosclerosis : Lessons from Type 1 Diabetes. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-481518
Modern Language Association (MLA)
Funk, Steven Daniel…[et al.]. Hyperglycemia and Endothelial Dysfunction in Atherosclerosis : Lessons from Type 1 Diabetes. International Journal of Vascular Medicine No. 2012 (2012), pp.1-19.
https://search.emarefa.net/detail/BIM-481518
American Medical Association (AMA)
Funk, Steven Daniel& Yurdagul, Arif& Orr, A. Wayne. Hyperglycemia and Endothelial Dysfunction in Atherosclerosis : Lessons from Type 1 Diabetes. International Journal of Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-19.
https://search.emarefa.net/detail/BIM-481518
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481518