Interactome of Radiation-Induced microRNA-Predicted Target Genes
Joint Authors
Chaudhry, M. Ahmad
Lhakhang, Tenzin W.
Source
Comparative and Functional Genomics
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The microRNAs (miRNAs) function as global negative regulators of gene expression and have been associated with a multitude of biological processes.
The dysfunction of the microRNAome has been linked to various diseases including cancer.
Our laboratory recently reported modulation in the expression of miRNA in a variety of cell types exposed to ionizing radiation (IR).
To further understand miRNA role in IR-induced stress pathways, we catalogued a set of common miRNAs modulated in various irradiated cell lines and generated a list of predicted target genes.
Using advanced bioinformatics tools we identified cellular pathways where miRNA predicted target genes function.
The miRNA-targeted genes were found to play key roles in previously identified IR stress pathways such as cell cycle, p53 pathway, TGF-beta pathway, ubiquitin-mediated proteolysis, focal adhesion pathway, MAPK signaling, thyroid cancer pathway, adherens junction, insulin signaling pathway, oocyte meiosis, regulation of actin cytoskeleton, and renal cell carcinoma pathway.
Interestingly, we were able to identify novel targeted pathways that have not been identified in cellular radiation response, such as aldosterone-regulated sodium reabsorption, long-term potentiation, and neutrotrophin signaling pathways.
Our analysis indicates that the miRNA interactome in irradiated cells provides a platform for comprehensive modeling of the cellular stress response to IR exposure.
American Psychological Association (APA)
Lhakhang, Tenzin W.& Chaudhry, M. Ahmad. 2012. Interactome of Radiation-Induced microRNA-Predicted Target Genes. Comparative and Functional Genomics،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-481525
Modern Language Association (MLA)
Lhakhang, Tenzin W.& Chaudhry, M. Ahmad. Interactome of Radiation-Induced microRNA-Predicted Target Genes. Comparative and Functional Genomics No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-481525
American Medical Association (AMA)
Lhakhang, Tenzin W.& Chaudhry, M. Ahmad. Interactome of Radiation-Induced microRNA-Predicted Target Genes. Comparative and Functional Genomics. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-481525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481525