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Medicinal Fungus Antrodia cinnamomea Inhibits Growth and Cancer Stem Cell Characteristics of Hepatocellular Carcinoma
Joint Authors
Liu, Yu-Kuo
Lee, Yu-Wei
Liu, Yu-Ming
Lan, Keng-Li
Chen, Yu-Jen
Tsai, Tung-Hu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Antrodia cinnamomea is an edible fungus commonly used in Asia as a well-known medicinal herb capable of treating drug intoxication and liver cancer.
Methods.
This study evaluated the anticancer activity of its biotechnological product, mycelial fermentation broth (AC-MFB) on hepatocellular carcinoma (HCC) by tetrazolium-based colorimetric assay in vitro and syngeneic Balb/c 1MEA.7R.1 tumor implantation model in vivo.
Given that cancer stem cell characteristics, such as angiogenesis, invasiveness, and migration, are known to cause recurrence, we further evaluated the effect of AC-MFB on cellular viability inhibition of HCC cells, angiogenic activity and migration of endothelial cells, and the release of proangiogenic factors from HCC cells.
Results.
We found that AC-MFB markedly inhibited the growth of HCC without hepatic enzyme abnormality.
This anti-HCC activity was validated by growth-inhibitory effects on both cultured murine 1MEA.7R.1 and human HA22T/VGH HCC cells.
For cancer stem cell characteristics, AC-MFB inhibited the cellular viability, migration, and tube formation activity of EA.
hy926 and SVEC4-10 endothelial cells.
Production of extracellular vascular endothelial growth factor and intracellular hypoxia-inducible factor-1 alpha from HCC cells was suppressed by AC-MFB.
Conclusion.
Antrodia cinnamomea could inhibit the growth and cancer stem cell characteristics of HCC cells.
American Psychological Association (APA)
Liu, Yu-Ming& Liu, Yu-Kuo& Lan, Keng-Li& Lee, Yu-Wei& Tsai, Tung-Hu& Chen, Yu-Jen. 2013. Medicinal Fungus Antrodia cinnamomea Inhibits Growth and Cancer Stem Cell Characteristics of Hepatocellular Carcinoma. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-481526
Modern Language Association (MLA)
Liu, Yu-Ming…[et al.]. Medicinal Fungus Antrodia cinnamomea Inhibits Growth and Cancer Stem Cell Characteristics of Hepatocellular Carcinoma. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-481526
American Medical Association (AMA)
Liu, Yu-Ming& Liu, Yu-Kuo& Lan, Keng-Li& Lee, Yu-Wei& Tsai, Tung-Hu& Chen, Yu-Jen. Medicinal Fungus Antrodia cinnamomea Inhibits Growth and Cancer Stem Cell Characteristics of Hepatocellular Carcinoma. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-481526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481526