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The Role of p38 MAPK in the Aetiopathogenesis of Psoriasis and Psoriatic Arthritis
Joint Authors
Sakkas, Lazaros I.
Bogdanos, Dimitrios P.
Liaskos, Christos
Mavropoulos, Athanasios
Rigopoulou, Eirini I.
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The pathogenetic mechanisms responsible for the induction of immune-mediated disorders, such as psoriasis, remain not well characterized.
Molecular signaling pathways are not well described in psoriasis, as well as psoriatic arthritis, which is seen in up to 40% of patients with psoriasis.
Signaling pathway defects have long been hypothesized to participate in the pathology of psoriasis, yet their implication in the altered psoriatic gene expression still remains unclear.
Emerging data suggest a potential pathogenic role for mitogen activated protein kinases p38 (p38 MAPK) extracellular signal-regulated kinase 1/2 (ERK1/2), and c-Jun N-terminal kinase (JNK) in the development of psoriasis.
The data are still limited, though, for psoriatic arthritis.
This review discusses the current data suggesting a crucial role for p38 MAPK in the pathogenesis of these disorders.
American Psychological Association (APA)
Mavropoulos, Athanasios& Rigopoulou, Eirini I.& Liaskos, Christos& Bogdanos, Dimitrios P.& Sakkas, Lazaros I.. 2013. The Role of p38 MAPK in the Aetiopathogenesis of Psoriasis and Psoriatic Arthritis. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-481527
Modern Language Association (MLA)
Mavropoulos, Athanasios…[et al.]. The Role of p38 MAPK in the Aetiopathogenesis of Psoriasis and Psoriatic Arthritis. Clinical and Developmental Immunology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-481527
American Medical Association (AMA)
Mavropoulos, Athanasios& Rigopoulou, Eirini I.& Liaskos, Christos& Bogdanos, Dimitrios P.& Sakkas, Lazaros I.. The Role of p38 MAPK in the Aetiopathogenesis of Psoriasis and Psoriatic Arthritis. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-481527
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481527