Ferric Carboxymaltose-Mediated Attenuation of Doxorubicin-Induced Cardiotoxicity in an Iron Deficiency Rat Model
Joint Authors
Cao, Gabriel
Mizzen, Lee
Funk, Felix
Dominici, Fernando Pablo
Rivas, Carlos
Toblli, Jorge Eduardo
Giani, Jorge Fernando
Source
Chemotherapy Research and Practice
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Since anthracycline-induced cardiotoxicity (AIC), a complication of anthracycline-based chemotherapies, is thought to involve iron, concerns exist about using iron for anaemia treatment in anthracycline-receiving cancer patients.
This study evaluated how intravenous ferric carboxymaltose (FCM) modulates the influence of iron deficiency anaemia (IDA) and doxorubicin (3–5 mg per kg body weight [BW]) on oxidative/nitrosative stress, inflammation, and cardiorenal function in spontaneously hypertensive stroke-prone (SHR-SP) rats.
FCM was given as repeated small or single total dose (15 mg iron per kg BW), either concurrent with or three days after doxorubicin.
IDA (after dietary iron restriction) induced cardiac and renal oxidative stress (markers included malondialdehyde, catalase, Cu,Zn-superoxide dismutase, and glutathione peroxidase), nitrosative stress (inducible nitric oxide synthase and nitrotyrosine), inflammation (tumour necrosis factor-alpha and interleukin-6), and functional/morphological abnormalities (left ventricle end-diastolic and end-systolic diameter, fractional shortening, density of cardiomyocytes and capillaries, caveolin-1 expression, creatinine clearance, and urine neutrophil gelatinase-associated lipocalin) that were aggravated by doxorubicin.
Notably, iron treatment with FCM did not exacerbate but attenuated the cardiorenal effects of IDA and doxorubicin independent of the iron dosing regimen.
The results of this model suggest that intravenous FCM can be used concomitantly with an anthracycline-based chemotherapy without increasing signs of AIC.
American Psychological Association (APA)
Toblli, Jorge Eduardo& Rivas, Carlos& Cao, Gabriel& Giani, Jorge Fernando& Funk, Felix& Mizzen, Lee…[et al.]. 2014. Ferric Carboxymaltose-Mediated Attenuation of Doxorubicin-Induced Cardiotoxicity in an Iron Deficiency Rat Model. Chemotherapy Research and Practice،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-481563
Modern Language Association (MLA)
Toblli, Jorge Eduardo…[et al.]. Ferric Carboxymaltose-Mediated Attenuation of Doxorubicin-Induced Cardiotoxicity in an Iron Deficiency Rat Model. Chemotherapy Research and Practice No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-481563
American Medical Association (AMA)
Toblli, Jorge Eduardo& Rivas, Carlos& Cao, Gabriel& Giani, Jorge Fernando& Funk, Felix& Mizzen, Lee…[et al.]. Ferric Carboxymaltose-Mediated Attenuation of Doxorubicin-Induced Cardiotoxicity in an Iron Deficiency Rat Model. Chemotherapy Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-481563
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481563