A Model of Left Ventricular Dysfunction Complicated by CAWS Arteritis in DBA2 Mice
Joint Authors
Nagi-Miura, Noriko
Adachi, Yoshiyuki
Hirata, Naoto
Hata, Satoru
Usui, Tatsuya
Ishibashi, Ken-ichi
Ohta, Shin
Ohno, Naohito
Yoshioka, Jiro
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
It was reported previously that a Candida albicans water-soluble fraction (CAWS), including a mannoprotein and β-glucan complex, has strong potency in inducing fatal necrotizing arteritis in DBA/2 mice.
In this study, histopathological changes and cardiac function were investigated in this system.
One mg/day of CAWS was given to DBA/2 mice via peritoneal injection for five days.
The CAWS-treated DBA/2 mice were induced aortitis and died at an incidence of 100% within several weeks.
Histological findings included stenosis in the left ventricular outflow tract (LVOT) and severe inflammatory changes of the aortic valve with fibrinoid necrosis.
Cardiomegaly was observed and heart weight increased 1.62 fold (P<0.01).
Echocardiography revealed a severe reduction in contractility and dilatation of the cavity in the left ventricle (LV): LV fractional shortening (LVFS) decreased from 71% to 38% (P<0.01), and the LV end-diastolic diameter (LVDd) increased from 2.21 mm to 3.26 mm (P<0.01).
The titer of BNP mRNA increased in the CAWS-treated group.
Severe inflammatory changes resulting from CAWS brought about lethal LV dysfunction by aortic valve deformation with LVOT stenosis.
This system is proposed as an easy and useful experimental model of heart failure because CAWS arteritis can be induced by CAWS injection alone.
American Psychological Association (APA)
Hirata, Naoto& Ishibashi, Ken-ichi& Usui, Tatsuya& Yoshioka, Jiro& Hata, Satoru& Adachi, Yoshiyuki…[et al.]. 2012. A Model of Left Ventricular Dysfunction Complicated by CAWS Arteritis in DBA2 Mice. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-481570
Modern Language Association (MLA)
Hirata, Naoto…[et al.]. A Model of Left Ventricular Dysfunction Complicated by CAWS Arteritis in DBA2 Mice. International Journal of Vascular Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-481570
American Medical Association (AMA)
Hirata, Naoto& Ishibashi, Ken-ichi& Usui, Tatsuya& Yoshioka, Jiro& Hata, Satoru& Adachi, Yoshiyuki…[et al.]. A Model of Left Ventricular Dysfunction Complicated by CAWS Arteritis in DBA2 Mice. International Journal of Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-481570
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481570