The Protective Effect of Lidocaine on Septic Rats via the Inhibition of High Mobility Group Box 1 Expression and NF-κB Activation
Joint Authors
Xu, Ying-Xue
Xing, Yan-Qiu
Zhang, Wen-Hua
Wang, Huan-Liang
Rong, Fei
Lei, Wei-Fu
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Lidocaine, a common local anesthetic drug, has anti-inflammatory effects.
It has demonstrated a protective effect in mice from septic peritonitis.
However, it is unknown whether lidocaine has effects on high mobility group box 1 (HMGB1), a key mediator of inflammation.
In this study, we investigated the effect of lidocaine treatment on serum HMGB1 level and HMGB1 expression in liver, lungs, kidneys, and ileum in septic rats induced by cecal ligation and puncture (CLP).
We found that acute organ injury induced by CLP was mitigated by lidocaine treatment and organ function was significantly improved.
The data also demonstrated that lidocaine treatment raised the survival of septic rats.
Furthermore, lidocaine suppressed the level of serum HMGB1, the expression of HMGB1, and the activation of NF-κB p65 in liver, kidneys, lungs, and ileum.
Taken together, these results suggest that lidocaine treatment exerts its protective effection on CLP-induced septic rats.
The mechanism was relative to the inhibitory effect of lidocaine on the mRNA expression level of HMGB1 in multiple organs, release of HMGB1 to plasma, and activation of NF-κB.
American Psychological Association (APA)
Wang, Huan-Liang& Xing, Yan-Qiu& Xu, Ying-Xue& Rong, Fei& Lei, Wei-Fu& Zhang, Wen-Hua. 2013. The Protective Effect of Lidocaine on Septic Rats via the Inhibition of High Mobility Group Box 1 Expression and NF-κB Activation. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-481578
Modern Language Association (MLA)
Wang, Huan-Liang…[et al.]. The Protective Effect of Lidocaine on Septic Rats via the Inhibition of High Mobility Group Box 1 Expression and NF-κB Activation. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-481578
American Medical Association (AMA)
Wang, Huan-Liang& Xing, Yan-Qiu& Xu, Ying-Xue& Rong, Fei& Lei, Wei-Fu& Zhang, Wen-Hua. The Protective Effect of Lidocaine on Septic Rats via the Inhibition of High Mobility Group Box 1 Expression and NF-κB Activation. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-481578
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481578