Effects of Low-Dose Testosterone Undecanoate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Male Osteoporosis with Low Serum Testosterone
Joint Authors
Huang, Wu
Zhan, Jun-Kun
Wang, Yi
Wang, Sha
Tan, Pan
Liu, Yuan
Liu, You-Shuo
Tang, Zhi-Yong
Wang, Yan-Jiao
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This prospective 2-year, single-center, randomized, placebo-controlled, open-label clinical trial was performed to evaluate the efficacy of low-dose testosterone undecanoate (TU) treatment on bone mineral density (BMD) and biochemical markers of bone turnover in elderly male osteoporosis with low serum testosterone.
A total of 186 elderly male osteoporosis patients with low serum testosterone were randomized into three groups: low-dose TU (20 mg, per day), standard-dose TU (40 mg, per day), and placebo group with a 24-month followup.
Since the 6th month in standard-dose TU group or since the 12th month followup in low-dose TU group and throughout the study, lumbar spine and femoral neck BMD and serum levels of free testosterone, estradiol, and bone alkaline phosphatase significantly increased.
There were no significant differences between groups of low-dose TU and standard dose TU in the percentage of changes of these data since the 18th month followup and throughout the study.
No side effects on prostate glands including prostate specific antigen were found.
In conclusion, low-dose TU (20 mg, per day) may be a cost effective and safe protocol for treating elderly male osteoporosis with low serum testosterone.
American Psychological Association (APA)
Wang, Yan-Jiao& Zhan, Jun-Kun& Huang, Wu& Wang, Yi& Liu, Yuan& Liu, You-Shuo…[et al.]. 2013. Effects of Low-Dose Testosterone Undecanoate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Male Osteoporosis with Low Serum Testosterone. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-481586
Modern Language Association (MLA)
Liu, You-Shuo…[et al.]. Effects of Low-Dose Testosterone Undecanoate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Male Osteoporosis with Low Serum Testosterone. International Journal of Endocrinology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-481586
American Medical Association (AMA)
Wang, Yan-Jiao& Zhan, Jun-Kun& Huang, Wu& Wang, Yi& Liu, Yuan& Liu, You-Shuo…[et al.]. Effects of Low-Dose Testosterone Undecanoate Treatment on Bone Mineral Density and Bone Turnover Markers in Elderly Male Osteoporosis with Low Serum Testosterone. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-481586
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481586